尋媶撪梕丂乚旙岥丄嶁杮乚
侾丏嵶朎庮釃壔偵娭梌偡傞怴偨側儅僀僋儘RNA嶻惗惂屼婡峔丂 偙傟傑偱偺変乆偺夝愅媦傃懠偺尋媶僌儖乕僾傜偺曬崘傛傝丄NF90媦傃NF90-NF45偼丄娞嵶朎偑傫丄旕彫嵶朎攛偑傫丄棏憙偑傫丄擕偑傫偺偑傫晹偱敪 尰偑崅偄偙偲偑柧傜偐偲側偭偰偄傞丅傑偨丄娞嵶朎偑傫丄巕媨栩偑傫桼棃偺嵶朎姅傪梡偄偨夝愅偵傛傝丄NF90-NF45偼偑傫嵶朎偺憹怋偵懀恑揑偵嶌梡偡 傞偙偲偑尒弌偝傟偰偄傞丅miRNA偲偑傫偲偺娭楢偵娭偟偰偼丄條乆側僞僀僾偺偑傫偵偍偄偰丄懡偔偺miRNA偺敪尰偑掅壓偟偰偍傝丄摉奩miRNA偼惓 忢慻怐偱偼偑傫梷惂場巕偲偟偰婡擻偟偰偄傞偲峫偊傜傟偰偄傞 (Li et al. Nature 2005)丅慜弎偺傛偆偵丄夁忚敪尰偟偨NF90-NF45偼pri-miRNA偺僾儘僙僢僔儞僌傪梷惂偡傞偙偲偱丄miRNA惗崌惉傪晧偵惂屼偡傞丅 廬偭偰偙傟傜偺抦尒傛傝変乆偼丄偑傫晹偵偍偄偰敪尰憹壛偟偨NF90-NF45偼丄偑傫梷惂miRNA偺嶻惗傪晧偵惂屼偡傞偙偲偵傛傝丄嵶朎庮釃壔偵懀恑 偟偰偄傞偺偱偼側偄偐偲嶌嬈壖愢傪棫偰丄偦偺専徹傪峴偭偰偄傞丅
丂偙傟傑偱偵杮壽戣偵娭偟偰偼丄娞嵶朎偑傫傪懳徾偵In vitro偱夝愅傪恑傔丄埲壓偺偙偲傪柧傜偐偵偟偨丅
丒娞偑傫嵶朎姅偵偍偄偰丄NF90-NF45偼偑傫梷惂miRNA偱偁傞miR-7偺嶻惗傪晧偵惂屼偡傞丅
丒NF90-NF45偺僲僢僋僟僂儞(KD)偵傛傝丄miR-7偺昗揑偱偁傞忋旂惉挿場巕庴梕懱(EGFR)偺敪尰偑掅壓偡傞丅
丒NF90-NF45偺KD偵傛傝丄EGFR偐傜偺嵶朎撪僔僌僫儖揱払偺壓棳偵埵抲偡傞Akt偺儕儞巁壔偑梷惂偝傟傞丅
丒NF90傕偟偔偼NF45 KD娞偑傫嵶朎姅偼憹怋偑梷惂偝傟傞丅
丂偙傟傜偺抦尒傛傝丄娞嵶朎偱敪尰憹壛偟偨NF90-NF45偼丄偑傫梷惂miR-7偺惗崌惉傪晧偵惂屼偟丄偦偺寢壥丄miR-7偺昗揑偱偁傞EGFR偺 敪尰偑憹壛偟丄EGFR偺壓棳偺嵶朎撪僔僌僫儖揱払偑妶惈壔偟丄偑傫嵶朎偺憹怋偑懀恑偡傞偺偱偼側偄偐偲峫偊傜傟偨 (恾俀) (Higuchi et al. JBC 2016)丅
