尋媶撪梕丂乚嶁杮 (嫟摨尋媶幰 屗崅愭惗)乚
俀丏儅僀僋儘RNA偺惗崌惉惂屼傪夘偟偨怴偨側嬝惉弉婡峔丂偑傫嵶朎姅傪梡偄偨In vitro偺夝愅偵傛傝丄NF90-NF45偺敪尰槾恑偵傛傞偑傫壔懀恑偼丄崅敪尰偟偨NF90-NF45偑丄偑傫梷惂miRNA偺嶻惗傪晧偵惂屼偡傞偙偲偵堦場偑偁傞偙偲偑暘偐偭偰偒偨 (Higuchi et al. JBC 2016)丅偦偙偱変乆偼丄偙偺偙偲傪In vivo偱 専徹偡傞偙偲傪栚揑偵丄慡恎偱NF90-NF45傪夁忚敪尰偡傞堚揱巕夵曄儅僂僗(NF90-NF45 double-transgenic mice: NF90-NF45 db-Tg mice)傪嶌惢偟丄庡梫慻怐偵偍偗傞偑傫敪惗偺桳柍傪専徹偡傞偙偲偲偟偨丅偟偐偟側偑傜NF90-NF45 db-Tg mice偵偍偗傞NF90-NF45偺敪尰槾恑偼丄崪奿嬝丄怱憻丄娽媴丄攛偱妋擣偝傟偨偺傒偱偁偭偨丅偙傟傑偱偺曬崘偱丄攛偵娭偟偰偼庤弍昗杮傪梡偄偨敪 尰夝愅偵傛傝丄偑傫晹偱NF90偺敪尰槾恑偑妋擣偝傟偰偄傞 (Guo et al. Clin Cancer Res 2008)丅偦偙偱尰嵼丄NF90-NF45 db-Tg mice偺攛偵偍偗傞庮釃宍惉偺桳柍傪慻怐妛揑偵専徹偟偰偄傞丅堦曽偱丄NF90-NF45 db-Tg mice偵偍偄偰偼丄埲壓偺尠挊側昞尰宆偑妋擣偝傟偨丅
丒NF90-NF45 db-Tg mice偼丄栰惗宆偲斾妑偟丄懱偑彫偝偄丅
丒NF90-NF45 db-Tg mice偼丄栰惗宆偲斾妑偟丄崪奿嬝検偑掅壓偟偰偄傞丅
丒NF90-NF45 db-Tg mice偺崪奿嬝偵偍偄偰偼妀偑拞怱偵嬊嵼偡傞嬝慻怐乮拞怱妀乯偑懡偔懚嵼偡傞丅堦斒偵惉弉偟偨嬝慻怐偼妀偑曈墢偵嬊嵼偡傞偺偵懳偟丄枹惉弉側嬝慻怐偱偼拞怱妀偲側傞丅
丂嬤擭丄嬝暘壔偵偼懡偔偺miRNA偑娭梌偟偰偄傞偙偲偑曬崘偝傟偰偄傞丅壛偊偰忋弎偺傛偆偵丄NF90-NF45偼miRNA惗崌惉偵懳偟梷惂揑偵婡擻偡傞偙偲偑抦傜傟偰偄傞(Sakamoto et al. MCB 2009)丅廬偭偰偙偺抦尒偲忋婰偺昞尰宆傛傝変乆偼丄崅敪尰偟偨NF90-NF45偼miRNA偺惗崌惉傪晧偵惂屼偡傞偙偲偵傛傝丄嬝惉弉傪梷惂偟偰偄傞偺偱偼側偄偐偲嶌嬈壖愢傪棫偰偨丅偦偺専徹傪恑傔偨寢壥丄壓婰偺偙偲偑柧傜偐偲側偭偨丅
丒 NF90-NF45 db-Tg mice偺崪奿嬝偵偍偄偰偼丄嬝暘壔娭楢miRNA偺嶻惗偑掅壓偟偰偄傞丅堦曽丄摉奩miRNA偺弶婜揮幨嶻暔偱偁傞pri-miRNA偺敪尰検偼丄憹壛 偟偰偄傞丅偙偺偙偲偼崪奿嬝偵偍偄偰夁忚敪尰偟偨NF90-NF45偑嬝暘壔娭楢miRNA偺弶婜揮幨嶻暔偺僾儘僙僢僔儞僌傪梷惂偟偰偄傞偙偲傪帵偟偰偄 傞丅
丒 NF90-NF45偵傛偭偰嶻惗偑梷惂偝傟傞嬝暘壔娭楢miRNA偼丄嬝幘姵(拞怱妀昦丄愭揤惈儈僆僷僠乕)偺尨場堚揱巕傪昗揑偲偡傞偙偲偑曬崘偝傟偰偄 傞丅梊應捠傝丄NF90-NF45 db-Tg mice偺崪奿嬝偵偍偄偰摉奩尨場堚揱巕偺敪尰偑憹壛偟偰偄傞偙偲偑暘偐偭偨丅
丂偙傟傜偺抦尒傛傝丄崪奿嬝偵偍偄偰敪尰憹壛偟偨NF90-NF45偼丄嬝暘壔娭楢miRNA偺惗崌惉傪晧偵惂屼偟丄偦偺寢壥丄摉奩miRNA偺昗揑偱偁 傞嬝幘姵(拞怱妀昦丄愭揤惈儈僆僷僠乕) 偺尨場堚揱巕偺敪尰偑憹壛偡傞偙偲偱丄嬝惉弉傪梷惂偡傞偺偱偼側偄偐偲峫偊傜傟偨 (恾俁) (Todaka et al. MCB 2015)丅
