亙榑暥亜
1. Kakinuma Y, Miyauchi T, Suzuki T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1兛. Clin Sci 103(Suppl 48):210S-214S, 2002

2. Yuki K, Suzuki T, Katoh S, Kakinuma Y, Miyauchi T, Mitsui Y. Endothelin-1 stimulates cardiomyocytes injury during mitochondrial dysfunction in culture. Eur J Pharmacol 431:163-170, 2001

3. Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Maeda S, Goto K, Yamaguchi I, Suzuki T. Endothelin-1 production is enhanced by rotenone, a mitochondrial complex 1 inhibitor, in cultured rat cardiomyocytes. Cardiovasc Pharmacol 38:850-858, 2001

4. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor Hypoxia-Inducible Factor-1兛 induced for impaired myocardial energy metabolism. Circulation 103:2387-2394, 2001

5. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Yamaguchi I, Goto K. Mitochondrial dysfunction of cardiomyocytes causing an impairment of cellular energy metabolism induces apoptosis, which is accompanied by an increase in cardiac ET-1 expression. J Cardiovasc Pharmacol 36:S201-204, 2000

6. Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Hayashi J, Goto K, Yamaguchi I. Mitochondrial dysfunction increases expression of endothelin-1 and followed by induction of apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. J Cardiovasc Pharmacol 36:S205-208, 2000

7. Murakoshi N, Miyauchi T, Kakinuma Y, Yuki K, Yamaguchi I. Impairment of cardiac energy metabolism in vivo causes hemodynamic abnormality and upregulation of myocardial preproendothelin-1 mRNA. J Cardiovasc Pharmacol 36:S128-131, 2000