儔儞僎儖僴儞僗嵶朎慻怐媴徢敪徢壖愢
 A hypothesis of Langerhans cell histiocytosis
乮LCH斀墳愢傪巟帩偡傞僨乕僞丄LCH庮釃愢傪巟帩偡傞僨乕僞傪暪偣偨敪徢壖愢乯

 尰嵼恑峴拞偺尋媶丗丂KAKEN

侾丏LCH斀墳愢傪巟帩偡傞僨乕僞乮IL-17:僂僀儖僗姶愼偵娭梌乯

  IL-17A receptor expression differs between subclasses of Langerhans cell
 histiocytosis, which might settle the IL-17A controversy.丂

丂亂嶲峫亃 LCH斀墳愢傪巟帩偡傞僨乕僞乮SHP-1:僀儞僞乕僼僃儘儞嶻惗偵娭梌乯

  Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single
-system Langerhans cell histiocytosis ] by immunohistochemistry
  Murakami I, Oka T, Kuwamoto S, Kato M, Hayashi K, Gogusev J, Imamura T,
  Morimoto A, Imashuku S, Yoshino T. Virchows Arch 2011,
  DOI: 10.1007/s00428-011-1090-1

丂儔儞僎儖僴儞僗嵶朎慻怐媴徢乮Langerhans cell histiocytosis = LCH乯偺垷宆偱偁傞
single-system LCH (LCH-SS)偲multisystem LCH (LCH-MS)偵偍偗傞専摙偱偡丅
 傛傝峀斖偵昦曄偑峀偑傞LCH-MS偺曽偑僼僅僗僼傽僞乕僛偱偁傞SHP-1偺敪尰偑
憹壛偟偰偄傞帠傪柶塽慻怐壔妛乮Immunohistochemistry=柶塽愼怓乯偵偰尒弌偟傑偟偨丅
  旂晢昦惈儕儞僷愡徢乮旂晢偺墛徢仺昞旂撪儔儞僎儖僴儞僗嵶朎偑儕儞僷愡偵戝検偵
堏摦偟儕儞僷愡偑庮戝偡傞幘姵乯偲儕儞僷愡偵敪惗偟偨LCH偺昦棟恌抐偵偍偗傞娪暿
偵栶棫偮棉袄偲偟偰傕婰嵹偟傑偟偨丅
SHP-1偼丄Toll-like receptor摍偐傜僀儞僞乕僼僃儘儞嶻惗僔僌僫儖揱払宱楬偵偍偗傞
婡擻偑抦傜傟偰偄傑偡丅 専摙偵嵺偟丄昹嶈娻尋媶彆惉嬥傪捀偒傑偟偨丅

俀丏LCH庮釃愢傪巟帩偡傞僨乕僞
丂Detection of molecular cytogenetic aberrations in Langerhans cell histiocytosis
of bone.
丂暓棷妛乮僼儔儞僗惌晎媼旓棷妛乯拞偵偝偣偰捀偄偨儔儞僎儖僴儞僗嵶朎慻怐媴徢
 乮LCH乯偵娭偡傞専摙偱偡丅

 棷妛愭偺僱僢働乕儖丒彫帣昦堾昦棟晹栧偵偼摉帪傕偐側傝昦棟堛偑偄傑偟偨偑丄2011
擭尰嵼昦棟堛偑15恖掱搙偄傞傛偆偱偡丅摨偠晘抧撪偵堛妛晹乮僷儕戞嘪戝妛乯偑偁傝丄
婎慴堛妛偺島嵗偼偦偪傜偵懏偟偰偄傑偡偑丄奜壢傗撪壢摍偺椪彴堛妛偼昦堾偺曽偵
島嵗偑偁傝傑偡丅昦棟乮昦棟恌抐妛乯傕椪彴堛妛偱偡偺偱昦堾偺曽偵強懏偟偰偄傑偡丅
尰嵼偺僔僃僼乮庡擟嫵庼乯偼丄third author 偺Fournet JC愭惗偱偡丅斵偼丄挿偄娫丄僷儕
傪棧傟偰僇僫僟偱昦棟堛傪偟偰偄傑偟偨偑丄Jaubert F嫵庼偺屻擟偲偟偰婣偭偰棃傑偟偨丅
偙偺昦棟晹栧偼丄昦棟恌抐妛傪庡偵偟偨晹栧偱偡丅偙偺晹栧偱摼傜傟偨嵽椏傪梡偄偰丄
CGH朄仚偵傛傞夝愅傗儅僀僋儘僒僥儔僀僩夝愅乮LOH夝愅乯傪偝偣偰捀偒傑偟偨丅
僱僢働乕儖丒彫帣昦堾偺晘抧撪偵婔偮偐偁傞INSERM仛偺儐僯僢僩偺堦偮偵傕弌擖傝偟
偮偮尋媶傪恑傔傑偟偨丅

   仚丗 CGH = comparative genomic hybridization
   仛丗 INSERM=Institut National de la Recherche Médicale
                                                      僼儔儞僗崙棫塹惗堛妛尋媶強

嶲峫丗
NCI (National Cancer Institute)僂僃僽僒僀僩偱偺堷梡 乮NCI偺儁乕僕丂reference 13乯 丂丂
Histiocytic Disorders of Children and Adults 偺p77 乮Google僽僢僋僗p81乯偱堷梡丅

  尰嵼傕丄尋媶僥乕儅偺堦偮偲偟偰LCH偵娭偡傞専摙傪懕偗偰偄傑偡 乮彆惉嬥丗擔杮
妛弍怳嫽夛乮2011-2013擭乯丄擔杮LCH尋媶夛乮2011擭乯丄暷崙慻怐媴徢嫤夛
乮2010擭乯摍乯丅
  2010擭丄儕儞僷媴憹怋幘姵丂娻恌椕巜恓偺偨傔偺昦棟恌抐僾儔僋僥傿僗 (拞嶳彂揦)
偺乽LCH乿偺崁傪丄 帺帯堛壢戝妛彫帣壢弝嫵庼乮尰嫵庼乯偺怷杮揘愭惗偲堦弿偵彂偐
偣偰偄偨偩偒傑偟偨丅