丂

丂丂丂丂丂

丂崅抦戝妛堛妛晹旝惗暔妛島嵗偼丄庡偵乽僸僩庮釃僂僀儖僗乿乽旝惗暔憄乮儅僀僋儘僶僀僆乕儉乯乿偺尋媶傪幘姵偲儕儞僋偝偣側偑傜峴偭偰偄傑偡丅
丂偝傜偵姶愼徢暘栰偺尋媶偵偲偳傑傜偢丄偙傟傑偱偺尋媶幚愌傪妶偐偟偐偟側偑傜庮釃妛丒寣塼妛偺尋媶傕暆峀偔峴側偭偰偄傑偡丅昦尨旝惗暔妛丄庮釃妛傪妛傫偱傒偨偄彅孨偺嶲壛傪婜懸偟偰偄傑偡丅

旝惗暔姶愼偲敪娻

丂僸僩偺娻慡懱偺20亾乣25%偼旝惗暔姶愼偑尨場偲側偭偰偄傑偡丅僂僀儖僗偱偼丄Epstein-Barr僂僀儖僗(EBV)偵傛傞埆惈儕儞僷庮丒敀寣昦傗堓娻丄僸僩T嵶朎敀寣昦僂僀儖僗I宆(HTLV-I)偵傛傞惉恖T嵶朎敀寣昦丄俠宆娞墛僂僀儖僗(HCV)偵傛傞娞娻丄僸僩僷僺儘乕儅僂僀儖僗(HPV)偵傛傞巕媨栩娻丒拞堲摢娻側偳偼偦偺戙昞偱偡丅偝傜偵2008擭偵偼僸僩偵娻傪庝婲偡傞戞俈斣栚偺庮釃僂僀儖僗偲偟偰儊儖働儖嵶朎億儕僆乕儅僂僀儖僗(MCPyV)偑曬崘偝傟傑偟偨丅嵶嬠偱偼僿儕僐僶僋僞乕丒僺儘儕嬠偵傛傞堓娻偑傛偔抦傜傟偰偄傑偡丅杮島嵗偱偼丄庡偵EBV丄MCPyV丄HPV丄僺儘儕嬠偺敪娻婡彉偵偮偄偰丄婎慴丒椪彴偺椉柺偐傜尋媶傪峴偭偰偄傑偡丅
丂庮釃僂僀儖僗偼偄偢傟傕帩懕姶愼偟丄姶愼屻挿偄擭寧傪宱偰丄嵶朎堚揱巕堎忢偲偺嫟摨嶌梡偺寢壥偲偟偰娻傪敪徢偣偟傔傑偡丅僂僀儖僗偲偄偆奜場梫場傪婎斦偵敪徢偡傞偄傢備傞乽姶愼娻乿偵偍偄偰丄僂僀儖僗懁場巕偑廻庡嵶朎偺娻壔傪懀恑偡傞暘巕婡峔偺夝愅傪峴偭偰偄傑偡丅

儊儖働儖嵶朎億儕僆乕儅僂僀儖僗偺偑傫壔婡峔

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旂晢旝惗暔憄乮儅僀僋儘僶僀僆乕儉乯偺僄僐儘僕乕偲幘姵偲偺娭學

丂恖懱偺條乆側晹埵偵偼忢嵼偡傞旝惗暔憄丄偄傢備傞儅僀僋儘僶僀僆乕儉偑懚嵼偟傑偡丅椺偊偽丄挵撪偵偼乽挵撪僼儘乕儔乿偲屇偽傟傞儅僀僋儘僶僀僆乕儉偑偁傝丄偦偺摦懺偑惗妶廗姷昦丒偑傫丒墛徢惈幘姵側偳偺幘姵偵娭傢偭偰偄傞偙偲偑柧傜偐偵偝傟偮偮偁傝丄嵟嬤拲栚傪廤傔偰偄傑偡丅儅僀僋儘僶僀僆乕儉偼旂晢偵傕偁傝乮旂晢僼儘乕儔乯丄1cm巐曽偺旂晢偵偼悢愮傕偺嵶嬠偑懚嵼偟傑偡丅傾僩僺乕惈旂晢墛姵幰偺旂怾晹偱偼墿怓僽僪僂媴嬠偑憹偊偰偄傑偡丅
丂堦曽丄僂僀儖僗傕旂晢儅僀僋儘僶僀僆乕儉傪慻惉偡傞偙偲偑傢偐偭偰偒偰偍傝丄偙偺僂僀儖僗孮廤傪僂僀儘乕儉偲屇傃傑偡丅変乆偼丄僸僩億儕僆乕儅僂僀儖僗偼寬峃側旂晢偵傕晄尠惈帩懕姶愼偟丄旂晢儅僀僋儘僶僀僆乕儉傪峔惉偡傞偙偲傪柧傜偐偵偟傑偟偨丅偦偺僂僀儖僗専弌棪傗僂僀儖僗検偼擭楊偲偲傕偵憹壛偡傞偙偲傪尒弌偟傑偟偨乮Journal of Infectious Diseases 213:1708-1716, 2016乯丅
丂 挿擭偵傢偨傞條乆側娐嫬梫場偵傛傞奜揑側巋寖傪庴偗懕偗傞偙偲偱丄旂晢儅僀僋儘僶僀僆乕儉偑曄壔偟丄旝惗暔乗廻庡娫偺憡屳嶌梡偵傛傝旂晢偺忬懺偑曄壔偟丄幘姵敪徢偵偮側偑傞偲梊憐偝傟傑偡丅摉島嵗偱偼丄偙偺乽旂晢僼儘乕儔乿偺摦懺偲幘姵偲偺娭學傪扵媶偟偰偄傑偡丅

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旝惗暔姶愼偲憿寣婍庮釃

丂憿寣婍埆惈庮釃偺惉場偲偟偰丄娻堚揱巕偺妶惈壔傗娻梷惂堚揱巕偺晄妶壔偵偮側偑傞genetic側堎忢丄偝傜偵偼DNA儊僠儖壔偵戙昞偝傟傞傛偆側epigenetic側堎忢偑偁偘傜傟傑偡丅偙傟傜偼暋嶨偵棈傒崌偄丄偝傜偵暿偺堚揱巕曄堎偑晅壛偝傟傞偙偲偱庮釃偑姰惉偝傟傞偲峫偊傜傟偰偄傑偡丅Epstein-Barr僂僀儖僗(EBV)傗僸僩T嵶朎敀寣昦僂僀儖僗I宆(HTLV-I)偵戙昞偝傟傞僂僀儖僗娭楢庮釃偵偍偄偰傕丄僂僀儖僗姶愼偼敪娻偺僀僯僔僄乕僔儑儞偵昁恵偱偡偑丄僾儘儌乕僔儑儞偵偼廻庡懁偺堚揱巕曄堎偑昁梫偲偝傟傑偡丅偙偺傛偆側娤揰偐傜丄杮島嵗偱偼僂僀儖僗偵傛傞敪娻儊僇僯僘儉偺傒側傜偢丄庮釃嵶朎懁偵偍偗傞genetic偍傛傃epigenetic側堚揱巕堎忢偺夝愅傕峴偭偰偄傑偡丅
丂 旝惗暔姶愼偵傛傞枬惈墛徢偑憿寣婍庮釃偺敪惗偵枾愙偵娭梌偟偰偄傑偡丅椺偊偽丄挿婜偵傢偨傞枬惈墛徢傪婎斦偵敪徢偡傞擽嫻娭楢儕儞僷庮乮EBV姶愼乯傗堓MALT儕儞僷庮乮僿儕僐僶僋僞乕僺儘儕嬠姶愼乯側偳丄偳偺傛偆側暘巕偑敪偑傫偵娭梌偡傞偺偐丄栐梾揑堚揱巕夝愅媄弍側偳傪嬱巊偟偰夝柧偵庢傝慻傫偱偄傑偡丅
丂摉島嵗偼丄悢懡偔偺憿寣婍庮釃桼棃嵶朎姅乮敀寣昦丒儕儞僷庮丒崪悜庮乯傪曐桳偟偰偄傑偡丅偙傟偼変乆偑條乆側儐僯乕僋側憿寣婍庮釃桼棃嵶朎姅傪撈帺偵庽棫偟偰偒偨惉壥偵傛傞傕偺偱偡丅偙偺傛偆側儊儕僢僩傪廩暘偵妶梡偟丄尋媶偵栶棫偰偰偄偒傑偡丅

EBV梲惈擽嫻娭楢儕儞僷庮 (PAL)

(A) CT幨恀丗庮釃偑嵍嫻暻偵怹弫丂
(B) 昦棟慻怐憸丗傃傑傫惈戝嵶朎宆B嵶朎惈儕儞僷庮丂
(C) EBER in situ hybridization:儕儞僷庮嵶朎偼EBV梲惈

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庮釃偵偍偗傞働儌僇僀儞偍傛傃働儌僇僀儞庴梕懱偺敪尰堎忢儊僇僯僘儉偺夝柧

丂嵶朎梀憱場巕働儌僇僀儞偼姶愼徢傗傾儗儖僊乕惈幘姵偩偗偱側偔庮釃偵偍偄偰傕廳梫側昦揑栶妱傪扴偭偰偄傑偡丅庮釃嵶朎偱傒傜傟傞働儌僇僀儞傗働儌僇僀儞庴梕懱偺敪尰堎忢偼庮釃嵶朎偺怹弫傗揮堏丄柶塽夞旔偲枾愙偵娭學偟偰偄傞偙偲偑抦傜傟偰偄傑偡丅偝傜嬤擭丄Th2嵶朎丄惂屼惈T嵶朎側偳偵慖戰揑偵敪尰偡傞働儌僇僀儞庴梕懱CCR4偑崅儗儀儖偱敪尰偡傞惉恖T嵶朎敀寣昦乮ATL乯偵懳偡傞峈CCR4峈懱栻乮儌僈儉儕僘儅僽乯帯椕偑擣壜偝傟偨傛偆偵丄働儌僇僀儞/働儌僇僀儞庴梕懱偼庮釃偵懳偡傞帯椕昗揑偲偟偰傕桳梡偱偡丅偟偐偟側偑傜丄庮釃偵偍偗傞働儌僇僀儞傗働儌僇僀儞庴梕懱偺敪尰堎忢儊僇僯僘儉偵偮偄偰偼晄柧側揰偑懡偔巆偝傟偰偄傑偡丅変乆偼偙傟傑偱偵丄ATL偵偍偗傞CCR4敪尰惂屼婡峔偺夝柧偐傜Fra-2/SOX4娻堚揱巕僇僗働乕僪傪尒弌偟丄嵶朎憹怋傗惗懚側偳ATL敪娻偵娭傢傞堚揱巕傪柧傜偐偵偟傑偟偨丅傑偨丄偙偺僇僗働乕僪偺捈愙揑側壓棳堚揱巕孮偵偼桳梡側峈庮釃栻偲偟偰拲栚偝傟偰偄傞慖戰揑僸僗僩儞扙傾僙僠儖壔峺慺乮HDAC乯慾奞嵻偺昗揑偺堦偮偱偁傞HDAC8偑懚嵼偟偰偄傑偟偨丅
丂 摉島嵗偱偼丄HTLV-1姶愼傪婲場偲偡傞ATL傪庡懱偵丄條乆側庮釃偵偍偗傞働儌僇僀儞/働儌僇僀儞庴梕懱偺敪尰惂屼婡峔偺夝柧傪幉偲偟偨帯椕傗恌抐偵桳梡側暘巕昗揑偺扵嶕傪峴偭偰偄傑偡丅

惉弉宆T嵶朎儕儞僷庮偵偍偗傞Fra-2-SOX4宱楬偺栶妱

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2010擭偐傜偺崅抦戝妛堛妛晹旝惗暔妛島嵗偺尋媶嬈愌乮塸岅榑暥乯偼偙偙傪僋儕僢僋偟偰壓偝偄丅