乽歬妎僐儈儏僯働乕僔儑儞丒屄懱擣幆婰壇婡峔偺夝柧乿
姂丂廏恖丂乮堛椕妛宯婎慴堛妛晹栧惗棟妛島嵗丂嫵庼乯

尋媶偺奣梫丗
僸僩偑庡偲偟偰帇妎傗挳妎偱忣曬傪摼偰偄傞偺偵懳偟丄懡偔偺摦暔偼壔妛暔幙傪庡梫側庤妡偐傝偵偟偰悽奅傪抦傞丅偙傟傜偺壔妛暔幙偺拞偵偼丄摨偠摦暔庬偺拠娫摨巑偑忣曬岎姺偵梡偄傞僼僃儘儌儞偑娷傑傟丄摦暔偑幮夛惗妶傪塩傓忋偱寚偐偣側偄傕偺偲側偭偰偄傞丅懡偔偺歁擕摦暔偼丄俀偮偺庡梫側擋偄忣曬張棟宯傪桳偟偰偄傞丅堦曽偼庡歬妎宯乮扨偵歬妎宯偲傕屇傇乯丄懠曽偼彌旲乮暃歬妎乯宯偲屇偽傟偰偄傞丅椉宯偲傕姶妎庴梕嵶朎偵敪尰偟偰偄傞俈夞枌娧捠宆偺G僞儞僷僋幙嫟栶宆庴梕懱偑擋偄傗僼僃儘儌儞傪庴梕偡傞丅庡歬妎宯偼丄婗敪惈偺擋偄暘巕傪姶搙傛偔姶抦偟丄峔憿揑偵娭楢偟偨擋偄暘巕娫偺僐儞僩儔僗僩傪嫮挷偟偰偙傟傜傪幆暿偡傞丅堦曽丄彌旲宯偼丄惈丄惗怋忬懺丄宯摑丄梒庒偐惉懱偐丄幮夛揑弴埵側偳傪摿挜偯偗傞僼僃儘儌儞忣曬偺張棟傪峴偄丄傂偄偰偼撪暘斿斀墳傗惗摼揑峴摦傪庝婲偡傞丅偙傟傜偺擋偄傗僼僃儘儌儞偑敪払丄岎旜丄暘曍偲偄偭偨惗奤偺摿掕偺帪婜乮姶庴惈婜乯偵嶞傝崬傑傟傞偲丄偦偺屻偺擋偄丒僼僃儘儌儞偵懳偡傞屄懱墳摎偑揔墳揑側傕偺偵曄壔偡傞丅傢傟傢傟偼偙傟傑偱偵丄嘆岎旜傪宊婡偵帗儅僂僗偵宍惉偝傟傞岎攝梇偺僼僃儘儌儞偺婰壇丄嘇怴惗巈儔僢僩偵偍偗傞擋偄妛廗丄嘊儔僢僩偵偍偗傞曣惈峴摦偺壗傟偵偍偄偰傕歬媴乮庡歬媴偁傞偄偼暃歬媴乯偑妛廗傗婰壇偵拞怱揑側栶妱傪壥偨偡擼晹埵偱偁傞偙偲傪帵偟丄偝傜偵恄宱丒僔僫僾僗丒暘巕儗儀儖偱偺儊僇僯僘儉傪夝柧偟偰偒偨丅傑偨丄彌旲婍偲暃歬媴偺嫟攟梴偵傛傞彌旲宯偺in vitro嵞峔惉宯傪妋棫偟丄彌旲僯儏乕儘儞偺暘壔丒惉弉傗彌旲宯偺恄宱夞楬宍惉偺儊僇僯僘儉傪柧傜偐偵偟偰偒偨丅杮尋媶偱偼丄偙傟傑偱偺惉壥傪婎斦偲偟偰丄歬妎僐儈儏僯働乕僔儑儞丒屄懱擣幆婰壇婡峔偵偍偗傞枌庴梕懱偺栶妱傪柧傜偐偵偡傞丅

姂丂廏恖乮偐偽丂傂偱偲乯

妛楌
徍榓 49擭  3寧丂幁帣搰戝妛擾妛晹廱堛妛壢懖嬈乮廱堛巘柶嫋庢摼乯
丂丂 55擭  3寧丂摽搰戝妛戝妛堾塰梴妛尋媶壢攷巑壽掱扨埵廋摼戅妛
丂丂(57擭9寧廋椆丄曐寬妛攷巑乯
怑楌
徍榓 55擭  4寧丂崅抦堛壢戝妛堛妛晹丂彆庤
丂丂 60擭  3寧丂働儞僽儕僢僕戝妛夝朥妛壢傊棷妛乮61擭7寧傑偱乯
丂丂 63擭  4寧丂崅抦堛壢戝妛堛妛晹丂彆嫵庼
暯惉   7擭  4寧丂幁帣搰戝妛擾妛晹丂嫵庼
丂丂丂9擭12寧丂崅抦堛壢戝妛乮15擭10寧傛傝崅抦戝妛乯堛妛晹丂嫵庼
丂丂 15擭  1寧丂Chemical Senses帍偺Executive Editor乮暯惉20擭12寧傑偱乯
丂丂 15擭11寧丂壀嶈崙棫嫟摨尋媶婡峔乮暯惉16擭4寧傛傝帺慠壢妛尋媶婡峔乯
丂丂丂丂丂丂丂  惗棟妛尋媶強娐嫬揔墳婡擻敪払尋媶晹栧乮媞堳晹栧乯嫵庼
丂丂(暯惉21擭3寧傑偱乯
丂丂 21擭  4寧丂擔杮枴偲擋妛夛丂夛挿
尰嵼偵帄傞

戙昞榑暥
1) Olfactory recognition: a simple memory system.
Brennan P, Kaba H, Keverne EB.
Science. 1990 Nov 30;250(4985):1223-6.

2) Induction of an olfactory memory by the activation of a metabotropic glutamate receptor.
Kaba H, Hayashi Y, Higuchi T, Nakanishi S.
Science. 1994 Jul 8;265(5169):262-4.

3) Olfactory imprinting in mammals.
Kaba H
In: Comparative Social Cognition, Watanabe S, Tsujii T, Keenan JP (eds), Keio University Press, 2007, pp 79-101.

乽僼傽乕僕儗僙僾僞乕暘巕偺摿掕偲婡擻夝柧乿
徏嶈丂栁揥乮堛椕妛宯婎慴堛妛晹栧旝惗暔妛島嵗丂弝嫵庼乯

尋媶偺奣梫
僶僋僥儕僆僼傽乕僕乮僼傽乕僕乯偼丄嵶嬠傊偺姶愼偺嵟弶婜偵丄旜晹愭抂晹偵懚嵼偡傞儕僈儞僪暘巕乮慇堐忬僞儞僷僋幙乯偲嵶嬠昞憌偵懚嵼偡傞儗僙僾僞乕暘巕乮僞儞僷僋幙丄摐嵔摍乯偲偺娫偺嬌傔偰摿堎惈偺崅偄寢崌傪夘偟偰丄嬠懱昞憌偵媧拝偡傞丅杮尋媶偱偼丄僼傽乕僕偑桳偡傞嵶嬠傊偺摿堎揑媧拝擻傪棙梡偟偰丄怴婯嵶嬠専弌朄偺奐敪丄偍傛傃嵶嬠偺摦暔姶愼偵偍偗傞嵶嬠昞憌暘巕乮儗僙僾僞乕暘巕乯偺栶妱偺夝柧傪栚巜偡丅
乮1乯僼傽乕僕儕僈儞僪暘巕偺摿掕偍傛傃惛惢丗僼傽乕僕僎僲儉偺傾僲僥乕僔儑儞偵傛傝丄儕僈儞僪暘巕偺堚揱巕傪悇掕偡傞丅摉奩堚揱巕嶻暔傪戝挵嬠撪偱戝検敪尰偝偣丄惛惢偡傞丅惛惢僞儞僷僋幙暘巕傪昗揑嵶嬠偵嶌梡偝偣丄寀岝丄敪怓丄嬠嬅廤斀墳摍傪棙梡偟偰摉奩暘巕偲嵶嬠偺寢崌傪妋擣偟丄僼傽乕僕儕僈儞僪偱偁傞偙偲傪妋擣偡傞丅摨帪偵懠嬠庬傊偺掅寢崌惈傪妋擣偡傞丅偦偺屻丄儕僈儞僪暘巕偲嵶嬠偺嵟揔側寢崌忦審丄専弌忦審傪専摙偟丄僼傽乕僕儕僈儞僪暘巕傪巊梡偡傞怴婯嵶嬠専弌朄偺奐敪傪栚巜偡丅
乮2乯嵶嬠懁僙僾僞乕暘巕偺摿掕偍傛傃惛惢丗廻庡嬠傪恊姅偲偟偰僼傽乕僕旕姶庴惈曄堎姅傪暘棧偡傞丅偦傟傜偺拞偱丄媧拝擻寚懝偵傛傝僼傽乕僕旕姶庴惈偲側偭偰偄傞曄堎姅偵偮偄偰丄奜枌僞儞僷僋幙丄帀幙丄摐嵔摍偺慻惉傪恊姅偲斾妑偟丄儗僙僾僞乕暘巕傪悇掕偡傞丅悇掕儗僙僾僞乕暘巕傪惛惢偟丄偙傟傪僼傽乕僕?嵶嬠偺媧拝幚尡宯偵揧壛偟丄嫞崌揑媧拝慾奞岠壥偺専摙偵傛傝丄儗僙僾僞乕暘巕偱偁傞偙偲偺妋擣傪峴側偆丅
堦曽丄媧拝曄堎姅偺暘棧偑崲擄側応崌偼丄捈愙嬠懱昞憌偺峔惉暘傪暘夋丄惛惢偟丄僼傽乕僕媧拝偵娭偡傞嫞崌揑慾奞幚尡偵傛傝儗僙僾僞乕暘巕偺摿掕傪峴側偆丅
乮3乯儗僙僾僞乕暘巕偺嵶嬠-廻庡乮摦暔乯嵶朎娫憡屳嶌梡傊偺娭梌偺専摙丗忋婰僼傽乕僕旕姶庴惈曄堎姅偲恊姅傪廻庡嵶朎攟梴宯偵揧壛偟丄嵶朎曄惈岠壥摍偺専摙偵傛傝丄儗僙僾僞乕暘巕偺嵶嬠?廻庡嵶朎娫憡屳嶌梡傊偺娭梌傪専摙偡傞丅傑偨惛惢儗僙僾僞乕暘巕傪捈愙摦暔攟梴嵶朎宯偵揧壛偟丄儗僙僾僞乕暘巕帺懱偺廻庡嵶朎傊偺塭嬁傪専摙偡傞丅儗僙僾僞乕暘巕偵偮偄偰丄嵶嬠-廻庡憡屳嶌梡傊偺塭嬁偑梊憐偝傟偨応崌丄儗僙僾僞乕寚懝曄堎姅偁傞偄偼儗僙僾僞乕暘巕傪儅僂僗偵愙庬偟丄嵶嬠姶愼偵偍偗傞儗僙僾僞乕暘巕乮嵶嬠昞憌暘巕乯偺栶妱傪専摙偡傞丅

徏嶈丂栁揥乮傑偮偞偒丂偟偘偺傇乯

妛楌丒怑楌
1977擭3寧丂嶳岥戝妛暥棟妛晹棟妛壢惗暔妛愱峌丂懖嬈
1985擭3寧丂峀搰戝妛戝妛堾棟妛尋媶壢攷巑屻婜壽掱丂扨埵庢摼戅妛
1986擭3寧丂岺妛攷巑丂乮峀搰戝妛乯
1986擭4寧丂崅抦堛壢戝妛丂暥晹嫵姱彆庤
1996擭7寧-1997擭4寧丂暥晹徣嵼奜尋媶堳丂
乮暷崙儅僒僠儏乕僙僢僣廈僴乕僶乕僪戝妛堛妛晹嵶朎惗暔妛嫵幒乯
2003擭1寧 丂攷巑乮堛妛乯丂乮媽崅抦堛壢戝妛乯
2003擭4寧丂崅抦堛壢戝妛丂暥晹嫵姱丂彆嫵庼
2003擭10寧 崅抦戝妛堛妛晹丂彆嫵庼
2007擭4寧丂崅抦戝妛堛妛晹丂弝嫵庼

戙昞榑暥
1) In silico and in vivo evaluation of bacteriophage 冇EF24C, a candidate for treatment of Enterococcus faecalis infections. Uchiyama J, Rashel M, Takemura I, Wakiguchi H, Matsuzaki S. Appl Environ Microbiol. 2008 Jul;74(13):4149-63. Epub 2008 May 2.

2) Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage 冇MR11. Rashel M, Uchiyama J, Ujihara T, Uehara Y, Kuramoto S, Sugihara S, Yagyu K, Muraoka A, Sugai M, Hiramatsu K, Honke K, Matsuzaki S. J Infect Dis. 2007 Oct 15;196(8):1237-47. Epub 2007 Sep 11.

3) Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage 冇MR11. Matsuzaki S, Yasuda M, Nishikawa H, Kuroda M, Ujihara T, Shuin T, Shen Y, Jin Z, Fujimoto S, Nasimuzzaman MD, Wakiguchi H, Sugihara S, Sugiura T, Koda S, Muraoka A, Imai S. J Infect Dis. 2003 Feb 15;187(4):613-24. Epub 2003 Feb 7.

乽戝擼暊懁晹偵偍偗傞恄宱幉嶕僈僀僟儞僗暘巕偺扵嶕偲婡擻夝柧乿
暯栰丂怢擇丂乮堛椕妛宯婎慴堛妛晹栧夝朥妛島嵗丂弝嫵庼乯

尋媶偺奣梫
戝擼暊懁晹偵偼旂幙帇彴楬丄旂幙愐悜楬丄帇彴旂幙楬丄慄忦懱崟幙宱楬側偳偄偔偮傕偺庡梫側恄宱夞楬偑懚嵼偟丄偙傟傜偺恄宱夞楬偼戝擼偺恄宱妶摦偵偼旕忢偵廳梫側栶妱傪壥偨偟偰偄傞丅偙傟傜偺恄宱夞楬宍惉偵偼僈僀僪億僗僩嵶朎偲屇偽傟傞摿庩側嵶朎傗揮幨場巕Pax6傗暘斿僞儞僷僋slit-1側偳條乆側暘巕偑娭梌偟偰偄傞偙偲偑偙傟傑偱偺尋媶偐傜曬崘偝傟偰偄傞丅巹偼偙傟傑偱偵OL僾儘僩僇僪僿儕儞偲偄偆嵶朎愙拝暘巕傪敪尒偟丄偙偺暘巕偑慄忦懱慄堐偺怢挿偵娭梌偟丄偙偺怢挿夁掱偑偦偺屻偺旂幙愐悜楬傗帇彴旂幙楬側偳偺恄宱夞楬宍惉偵廳梫側偼偨傜偒傪偟偰偄傞偙偲傪帵偟偨丅偙偺傛偆偵戝擼暊懁晹偺恄宱夞楬宍惉婡峔偺尋媶偼恑傫偱偒偨偑丄傑偩廫暘側夝柧偵偼帄偭偰偄側偄丅椺偊偽丄慄忦懱慄堐偑扺憮媴傪捠夁偟廂懇偟偰偄偔婡峔傗帇彴旂幙慄堐偑戝擼旂幙偵岦偐偭偰怢挿偟偰偄偔婡峔側偳傢偐傜側偄偙偲偼悢懡偄丅
偙偺椞堟偵偍偗傞恄宱夞楬宍惉偺暘巕婡峔傪柧傜偐偵偡傞偨傔偵丄杮尋媶偱偼恄宱幉嶕偺嵶朎枌忋偵懚嵼偡傞僈僀僟儞僗暘巕偺扵嶕偲偦傟傜偺婡擻夝柧傪峴偭偰偄偔丅儅僂僗擼偵偍偄偰偙偺椞堟偵敪尰偟偰偄傞僈僀僟儞僗暘巕傪尒偮偗丄偦傟傜偺暘巕偺婡擻傪攟梴宯傗曄堎儅僂僗傪梡偄偰夝愅傪峴偆丅摿偵斀敪嶌梡偺偁傞僙儅僼僅儕儞/僾儗僉僔儞傗嵶朎愙拝偱偁傞僾儘僩僇僪僿儕儞側偳偵偮偄偰挷傋丄枹抦偺恄宱僈僀僟儞僗婡峔傪柧傜偐偵偟偰偄偔丅

暯栰丂怢擇乮傂傜偺丂偟傫偠乯

妛楌丒怑楌
1987擭丂嫗搒戝妛棟妛晹懖丅
1992擭丂嫗搒戝妛戝妛堾攷巑壽掱廋椆丅棟妛攷巑丅
壀嶈崙棫嫟摨尋媶婡峔婎慴惗暔妛尋媶強彆庤丄撿僇儕僼僅儖僯傾戝妛僪僂僸乕僯乕娽尋媶強攷巑尋媶堳丄僸儏乕儅儞僼儘儞僥傿傾僒僀僄儞僗僾儘僌儔儉挿婜僼僃儘乕丄垽抦導怱恎忈奞幰僐儘僯乕敪払忈奞尋媶強尋媶堳丄壢妛媄弍怳嫽婡峔丂偝偒偑偗尋媶俀侾尋媶堳丄棟壔妛尋媶強敪惗嵞惗憤崌壢妛尋媶僙儞僞乕尋媶堳側偳傪宱偰2008擭傛傝尰怑丅丂

戙昞榑暥
1) Pioneers in the ventral telencephalon: The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
Hirano S.
Cell Adh Migr. 2007 Oct;1(4):176-8.

2) OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections.
Uemura M, Nakao S, Suzuki ST, Takeichi M, Hirano S.
Nat Neurosci. 2007 Sep;10(9):1151-9.

3) Expression of a novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain.
Hirano S, Yan Q, Suzuki ST.
J Neurosci. 1999 Feb 1;19(3):995-1005.

乽僙儗僋僠儞儕僈儞僪傪傕偮KL-6/MUC1暘巕偺敪尰婡峔偺夝柧乿
墶嶳丂彶恗乮堛椕妛宯椪彴堛妛晹栧寣塼�屇媧婍撪壢妛島嵗丂嫵庼乯

尋媶偺奣梫
偙傟傑偱偵変乆偼娫幙惈攛墛偺寣惔儅乕僇乕偲偟偰梡偄傜傟偰偄傞KL-6偺尋媶奐敪偵実傢偭偰偒偨丅尰嵼丄KL-6偼擭娫100枩夞埲忋應掕偝傟偰偍傝丄寣惔儅乕僇乕偲偟偰偺抧埵偑妋棫偝傟偰偄傞丅KL-6偼枌娧捠宆摐僞儞僷僋偱偁傞MUC1暘巕忋偵敪尰偝傟傞摐嵔偱偁傝丄KL-6偺峔憿偼枹偩柧傜偐偱偼側偄偑丄攛朎2宆忋旂傪庡側嶻惗尮偲偟丄懡偔偺娫幙惈攛墛偱忋徃偡傞丅嵟嬤丄KL-6偑媫惈攛懝彎/媫惈屇媧懀敆徢岓孮乮ALI/ARDS乯偵偍偄偰傕忋徃偡傞偙偲偑柧敀偵側偭偰偄傞丅変乆偺専摙偱偼丄ALI/ARDS偵偟偽偟偽崌暪偟丄偐偮巰場偲側傞斈敪惈寣娗撪嬅屌徢岓孮乮DIC乯偺敪惗偲KL-6偺抣偑娭學偡傞偙偲傪柧傜偐偵偟偰偄傞丅
僙儗僋僠儞偼庬乆偺嵶朎昞柺偵敪尰偟丄偦偺儕僈儞僪娫偱柶塽偁傞偄偼墛徢嵶朎娫偺憡屳嶌梡偵娭梌偟偰偄傞丅峈僙儗僋僠儞帯椕偑幚尡揑側ALI/ARDS儌僨儖偵偍偄偰桳岠偱偁傞偙偲偑曬崘偝傟偰偄傞丅嵟嬤丄変乆偼堦晹偺娻嵶朎偺KL-6/MUC1暘巕忋偵僙儗僋僠儞儕僈儞僪偑敪尰偟偰偍傝丄椺偊偽僔傾儕儖儖僀僗a暘巕偵懳偡傞峈懱偲KL-6峈懱偱僒儞僪僀僢僠偟偰應掕壜擻側暘巕乮乬SLAK乭偲柦柤乯傪寣拞偱應掕偟丄擹搙偑崅抣偱偁傞偲丄揮堏偑懀恑偝傟丄撈棫偟偨攛態娻偺梊屻晄椙場巕偲側傞偙偲傪柧傜偐偵偟偨丅SLAK偼椙惈幘姵偱傕忋徃偡傞偙偲偑偁傝丄摿偵媫惈屇媧懀敆徢岓孮乮ARDS乯偱偼崅抣偵側傝傗偡偄丅偲偙傠偑丄摨偠偔KL-6偑挊偟偔忋徃偡傞媫惈宆夁晀惈攛墛偱偼丄SLAK偼忋徃偟側偄丅偙偺棟桼偼尰帪揰偱偼晄柧偱偁傞丅
嬤擭偺曬崘偱偼丄娻惈儉僠儞偲僙儗僋僠儞偺憡屳嶌梡偑丄偑傫偱擣傔傜傟傞Trousseau徢岓孮偺尨場偲怺偔娭傢偭偰偄傞偙偲偑帵偝傟偰偄傞丅僙儗僋僠儞儕僈儞僪傪娷傔偨庬乆偺摐嵔偑娻惈儉僠儞偵敪尰偟丄柶塽偁傞偄偼嵶朎娫斀墳丄嵶朎娫愙拝偵娭梌偡傞偙偲偑抦傜傟偰偄傞丅娻惈儉僠儞偺惷柆搳梌偵傛傝丄慻怐場巕傗僄儞僪僩僉僔儞偺娭梌柍偟偵丄寣娗撪偺寣彫斅朙晉側寣愷偺惗惉傪堷偒婲偙偡偙偲偑柧傜偐偵偝傟偰偄傞丅
杮尋媶偱偼丄僙儗僋僠儞儕僈儞僪傪傕偮KL-6/MUC1偑丄椙惈幘姵偱偁傞ARDS偵偍偗傞斈敪惈寣娗撪嬅屌徢岓孮乮DIC乯偲娭楢偡傞偐偳偆偐傪柧妋偵偡傞丅傑偨丄偦傟偑柧妋偵側傟偽丄摿偵娻嵶朎偵偍偗傞僙儗僋僠儞儕僈儞僪傪傕偮KL-6/MUC1摿偵SLAK偺敪尰婡峔傪夝柧偟丄ARDS側偳堦晹偺椙惈幘姵偱傕敪尰偡傞婡彉傪柧傜偐偵偟丄廳撃側崌暪徢偱偁傞DIC傪梊杊偡傞偙偲偵偮側偘偨偄偲峫偊偰偄傞丅

墶嶳丂彶恗乮傛偙傗傑丂偁偒傂偲乯

棯楌
徍榓 58 ( 1983 ) 擭丂晉嶳堛壢栻壢戝妛 丂堛妛晹堛妛壢懖嬈
徍榓 61 ( 1986 ) 擭丂暷崙僔僇僑戝妛 柶塽妛 Research丂Fellow乮2擭娫乯
暯惉丂3 ( 1991 ) 擭丂垽昋戝妛堛妛晹乮戞擇撪壢乯丂彆庤
暯惉 12 ( 2000 ) 擭丂丂丂丂丂丂丂摨丂島巘
暯惉 15 ( 2003 ) 擭丂峀搰戝妛戝妛堾暘巕撪壢妛乮媽戞擇撪壢乯丂島巘
暯惉 17 ( 2005 ) 擭丂丂丂丂丂丂丂摨丂彆嫵庼
暯惉 19 ( 2007 ) 擭丂崅抦戝妛堛妛晹丂嫵庼 乮寣塼丒屇媧婍撪壢妛丄媽戞嶰撪壢乯
尰嵼偵帄傞

戙昞榑暥
1) Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome. Nakashima T, Yokoyama A, Ohnishi1 H, Hamada H, Ishikawa N, Haruta Y, Hattori N, Tanigawa K, Kohno N.
J Intern Med, 2008;263:432-9

2) Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis. Nakashima T, Yokoyama A, Ohnari Y, Syoda H, Haruta Y, Hattori N, Naka T, Kohno N.
J Allergy Clin Immunol, 2008;121:1269-76.

3) Airflow Limitation in Smokers is Associated with Subclinical Atherosclerosis. Iwamoto H, Yokoyama A, Kitahara Y, Ishikawa N, Haruta Y, Yamane K, Hattori N, Hara H, Kohno N.
Am J Respir Crit Care Med. 2009;179:35-40

乽擼撪嵶朎枌儕儞帀幙偑岎姶恄宱亅暃恡悜幙宯晩妶偺拞悤惈惂屼偵壥偨偡栶妱偺夝柧乿
惔悈丂岶梞乮堛椕妛宯婎慴堛妛晹栧栻棟妛島嵗丂弝嫵庼乯

尋媶偺奣梫
丂嵶朎枌偼丄帺恎偵慻傒崬傑傟偨庬乆偺僞儞僷僋幙乵庴梕懱丄GTP寢崌僞儞僷僋幙丄儂僗儂儕僷乕僛 C乮PLC乯側偳乶傪夘偟偰嵶朎奜忣曬傪嵶朎撪偵揱払偡傞応偲偟偰婡擻偡傞偺傒側傜偢丄嵶朎枌峔惉惉暘偑忣曬揱払暔幙偺尨嵽椏偲側傞側偳丄惗柦妶摦偵廳梫側栶妱傪扴偭偰偄傑偡丅
丂巹払偼丄嵶朎枌儕儞帀幙桼棃偺忣曬揱払暔幙偱偁傞僾儘僗僞僲僀僪椶偵拝栚偟偰丄僗僩儗僗偵懳偡傞惗懱斀墳婡峔傪丄僗僩儗僗斀墳偵廳梫側栶妱傪扴偆岎姶恄宱-暃恡悜幙宯乮SA宯乯偲偺娭楢偱尋媶偟偰偒傑偟偨丅偦偺寢壥丄擼撪僾儘僗僞僲僀僪椶偑SA宯偺晩妶偵娭梌偡傞偙偲傪柧傜偐偵偟傑偟偨乮Shimizu et al., Eur J Pharmacol 2006;541:152-7; Lu et al., Eur J Pharmacol 2008;590:177-84; Sasaki et al., Eur J Pharmacol 2008;592:81-6; Shimizu and Yokotani, Eur J Pharmacol 2009;606:77-83; Eur J Pharmacol 2009;611:30-4乯丅
丂偦偙偱丄SA宯晩妶斀墳偵娭傢傞僾儘僗僞僲僀僪椶偺擼撪嶻惗婡峔傪夝愅偟偨強丄嫽枴怺偄偙偲偵丄廬棃偐傜抦傜傟偰偄傞儂僗儂儕僷乕僛A2傪夘偟偨嶻惗婡峔偱偼側偔丄PLC傪夘偟偨嶻惗婡峔偱偁傞偙偲偑傢偐傝傑偟偨丅偡側傢偪丄嘆擼撪PLC乛僕傾僔儖僌儕僙儘乕儖儕僷乕僛傪夘偟偰嶻惗偝傟偨2-傾儔僉僪僲僀儖僌儕僙儘乕儖乮2-AG乯偑擼撪僾儘僗僞僲僀僪椶偺嶻惗尮偲偟偰丄杮晩妶斀墳偺懀恑偵娭梌偡傞偙偲傪柧傜偐偵偟傑偟偨乮Shimizu et al., Eur J Pharmacol 2004;499:99-105; Eur J Pharmacol 2005;514:151-8; Eur J Pharmacol 2007;571:138-44; Eur J Pharmacol 2010;641:54-60; Eur J Pharmacol 2011;658:123-31; Eur J Pharmacol 2012;691:93-102; Shimizu and Yokotani, Eur J Pharmacol 2008;582:62-9乯丅壛偊偰丄嘇偙偺2-AG偼嫮椡側擼撪戝杻乮僄儞僪僇儞僫價僲僀僪: eCB乯偲偟偰丄擼撪僇儞僫價僲僀僪CB1庴梕懱乮偄傢備傞戝杻庴梕懱乯傪夘偟丄杮晩妶斀墳傪梷惂惈偵傕惂屼偡傞偙偲傪柧傜偐偵偟傑偟偨乮Shimizu and Yokotani, Eur J Pharmacol 2008;582:62-9; Shimizu et al., Eur J Pharmacol 2010;641:54-60; Eur J Pharmacol 2011;658:123-31乯丅埲忋偐傜丄2-AG偑SA宯晩妶偵懳偟偰嘆偍傛傃嘇偺栶妱丄偡側傢偪丄擇曽岦惈偺栶妱傪桳偡傞儐僯乕僋側暘巕偲偟偰擼撪偱婡擻偟偰偄傞偙偲偑傢偐傝傑偟偨乮Shimizu et al., J Pharmacol Sci 2013;121:157-71乯丅
丂杮尋媶偱偼丄SA宯晩妶偺拞悤惈惂屼婡峔傪丄擼撪嵶朎枌儕儞帀幙桼棃偺惗棟妶惈暔幙乮摿偵僾儘僗僞僲僀僪椶偍傛傃eCB乯偍傛傃偦偺庴梕懱偲偺娭楢偱柧傜偐偵偡傞偙偲傪栚揑偲偟偰偄傑偡丅僗僩儗僗斀墳偵廳梫側栶妱傪扴偆SA宯偺夁忚丒堎忢側晩妶偼丄崅寣埑徢側偳偺僗僩儗僗娭楢幘姵傪庝婲偟傑偡偑丄偙傟傜幘姵傪崻帯偡傞偨傔偵偼丄SA宯晩妶惂屼傪扴偆丄拞悤恄宱宯傪昗揑偲偟偨帯椕愴棯傪峫偊傞昁梫偑偁傝傑偡丅杮尋媶偺惉壥偼丄惗懱偺僗僩儗僗揔墳婡峔夝柧側傜傃偵僗僩儗僗娭楢幘姵偵懳偡傞崻杮揑側帯椕朄奐敪偺懌偑偐傝偵側傞偙偲偑婜懸偝傟傑偡丅

惔悈丂岶梞乮偟傒偢丂偨偐傂傠乯

庴徿
2012擭丂丂3寧丂戞85夞擔杮栻棟妛夛擭夛桪廏敪昞徿

戙昞榑暥
1) Tanaka K, Shimizu T, Yanagita T, Nemoto T, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M. Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat. Br J Pharmacol, 171, 202-213, 2014

2) Shimizu T, Tanaka K, Yokotani K. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. J Pharmacol Sci, 121, 157-171, 2013

3) Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yokotani K. Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (亇)-epibatidine-induced activation of central adrenomedullary outflow in rats. Eur J Pharmacol, 691, 93-102, 2012

4) Shimizu T, Yokotani K. Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. Eur J Pharmacol, 582, 62-69, 2008

5) Shimizu T, Uehara T, Nomura Y. Possible involvement of pyruvate kinase in acquisition of tolerance to hypoxic stress in glial cells. J Neurochem, 91, 167-175, 2004

乽摐帀幙儔僼僩傪応偲偟偨T嵶朎偺峈尨擣幆婡峔乿
塅崅丂宐巕乮堛椕妛宯婎慴堛妛晹栧柶塽妛島嵗丂嫵庼乯

尋媶偺奣梫
T嵶朎偼丄帺屓偺枌抈敀幙偱偁傞MHC (Major Histocompatibility Complex)暘巕偵丄帺屓丄旕帺屓桼棃偺儁僾僠僪偑寢崌偟偨暋崌懱傪尒暘偗偰丄偦傟偧傟丄帺屓姲梕偁傞偄偼峌寕偲偄偆懳徠揑側墳摎傪婲偙偟傑偡丅偙偺MHC-儁僾僠僪偺尒暘偗偺暘巕婡峔偼柧傜偐偵側偭偰偄傑偣傫丅巹偨偪偼丄偙偺尒暘偗偑丄T嵶朎儗僙僾僞乕乮TCR乯偵懳偡傞侾暘巕儗儀儖偱偺寢崌恊榓惈偵偍偄偰偼丄偨偐偩偐悢攞掱搙偺嵄嵶側堘偄偵偡偓側偄偙偲傪娤嶡偟傑偟偨丅偙偺傢偢偐側寢崌恊榓惈偺堘偄偑丄堎側傞枌庴梕懱暘巕孮偺墳摎偺堘偄傪惗傓棟桼傪扵傝偨偄偲峫偊偰偄傑偡丅
TCR偵傛傞堎暔擣幆墳摎偼丄嵶朎枌忋偺摐帀幙儅僀僋儘僪儊僀儞乮儔僼僩乯傪応偲偟偰婲偙傝傑偡丅偦偙偱丄摐帀幙崌惉峺慺偺KO儅僂僗傪梡偄偰儔僼僩偺暔惈傪曄壔偝偣丄峈尨擣幆偵塭嬁偑弌傞偐丄挷傋偰偄傑偡丅堦曽丄儔僼僩偺暔惈偵塭嬁傪梌偊傞壜擻惈偺偁傞帀幙傪曄壔偝偣丄T嵶朎偺墳摎傪挷傋偰偄傑偡丅
傑偨丄儔僼僩傪応偲偡傞斀墳偺偆偪丄惗懱偺晄梡偵側偭偨嵶朎偺怴捖戙幱偺帇揰偐傜丄巕媨撪枌偺寧宱廃婜偵偲傕側偆扙棊丒嵞惗偺儊僇僯僘儉傪扵傝丄偙傟傑偱尨場偑柧傜偐偵側偭偰偄側偄巕媨撪枌徢偺昦懺惗棟偵偮偄偰棟夝傪怺傔偨偄偲峫偊偰偄傑偡丅
忋婰偺婎慴尋媶偑恑傔偽丄摿掕偺峈尨偵懳偡傞傾儗儖僊乕傗帺屓柶塽幘姵偵懳偟丄摿掕偺峈尨偵懳偡傞柶塽墳摎偺傒傪梷偊丄昦尨旝惗暔偵懳偡傞柶塽墳摎偼惓忢偵曐偮媄弍偺奐敪偵偮側偘傞偙偲偑偱偒傞偐傕偟傟傑偣傫丅堦曽丄巹偨偪偑偙傟傑偱偺尋媶偱恎偵偮偗偨丄MHC-儁僾僠僪寢崌摿惈偺夝愅傗丄T嵶朎偺夝愅媄弍傪妶梡偟偰丄儔僼僩偲偄偆斀墳応傪偆傑偔棙梡偟偨丄偑傫傗擄帯惈僂僀儖僗偵懳偡傞儁僾僠僪柶塽椕朄偺奐敪傪偟偰偄傑偡丅

戙昞榑暥
1) A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein.
Keiko Udaka, Theodore J. Tsomides,? Herman N. Eisen.
Cell丂1992 69: 989-998

2) Empirical evaluation of a dynamic experiment design method for prediction of MHC class I-binding peptides.
Keiko Udaka, Hiroshi Mamitsuka, Yukinobu Nakaseko and Naoki Abe.

乽嵶朎枌儅僀僋儘僪儊僀儞偵偍偗傞暘巕娫僱僢僩儚乕僋偺夝柧乿
杮壠丂岶堦丂乮堛椕妛宯婎慴堛妛晹栧惗壔妛島嵗丂嫵庼乯

尋媶奣梫
忣曬揱払丄嵶朎愙拝丄僞儞僷僋桝憲偺傛偆側嵶朎枌偑娭梌偡傞廳梫側惗柦尰徾偼丄枌儅僀僋儘僪儊僀儞傪夘偡傞偙偲偑抦傜傟偰偄傑偡丅偟偐偟側偑傜丄偦偺傛偆側枌儅僀僋儘僪儊僀儞偑惗棟忦審壓偱偳偺傛偆偵宍惉偝傟傞偐傪挷傋傞偙偲偼崲擄偱偡丅巹払偼丄惗偒偰偄傞嵶朎偺嵶朎昞柺偵懚嵼偡傞擟堄偺暘巕偺僷乕僩僫乕傪尒偮偗傞偨傔偺怴偟偄曽朄傪奐敪偟傑偟偨丅偙偺曽朄偼丄 Enzyme-Mediated Activation of Radical Source (EMARS)偲柦柤偟傑偟偨偑丄壦嫶嵻偺傾儕乕儖傾僕僪價僆僠儞傪惣梞傢偝傃儁儖僆僉僔僟乕僛乮HRP乯偱妶惈壔偡傞揰偑摿挜偱偡丅HeLa S3嵶朎偱偼丄懡偔偺庬椶偺庴梕懱僠儘僔儞僠儘僔儞僉僫乕僛偑b1僀儞僥僌儕儞偲夛崌偟偰偄傞偑丄帀幙儔僼僩偺儅乕僇乕偲偟偰傛偔巊傢傟傞僈儞僌儕僆僔僪GM1偼悢彮側偄庴梕懱僠儘僔儞僠儘僔儞僉僫乕僛偲偺傒夛崌偟偰偄傞偙偲傪尒弌偟傑偟偨丅偙偺傛偆偵丄EMARS朄偼丄惗棟揑忦審壓偱婲偙傞嵶朎昞柺暘巕娫憡屳嶌梡傪惗壔妛揑偵摨掕偡傞栐梾揑側傾僾儘乕僠偱偡丅
杮嫆揰僾儘僕僃僋僩偵偍偄偰丄EMARS朄偲枌儅僀僋儘僪儊僀儞峈懱嶌惢朄傪婎斦媄弍偲偟偰丄奺庬昦懺嵶朎偺嵶朎枌忋暘巕娫僱僢僩儚乕僋傪夝柧偟丄暘巕娫憡屳嶌梡傪昗揑偲偡傞夋婜揑側帯椕朄偺奐敪傪栚巜偟傑偡丅婛偵丄廬棃朄偱偼尒偮偗傞偙偲偺偱偒側偐偭偨嵶朎枌忋暘巕娫憡屳嶌梡傪尒弌偟偰偍傝丄偦偺惗棟揑栶妱傪柧傜偐偵偡傞偙偲偵傛偭偰丄偙傟傑偱梊婜偝傟側偐偭偨惗懱僔僗僥儉偺惂屼婡峔偑柧傜偐偵側傞壜擻惈偑偁傝傑偡丅

妛楌
1983丂杒奀摴戝妛堛妛晹懖嬈
1986丂杒奀摴戝妛戝妛堾堛妛尋媶壢攷巑壽掱拞戅
怑楌
1987-1995丂丂杒奀摴戝妛堛妛晹晬懏娻尋媶巤愝惗壔妛晹栧彆庤丒島巘
1995-1999丂丂戝嶃晎棫曣巕曐寬憤崌堛椕僙儞僞乕尋媶強庡擟尋媶堳
1999-2003丂丂戝嶃戝妛戝妛堾堛妛宯尋媶壢惗壔妛丒暘巕惗暔妛島嵗彆嫵庼
2003-present丂崅抦堛壢戝妛堚揱巕昦懺惂屼妛嫵幒
乮尰丂崅抦戝妛嫵堢尋媶晹堛椕妛宯婎慴堛妛晹栧惗壔妛島嵗乯嫵庼
2008-present丂崅抦戝妛堛妛晹晬懏僔僗僥儉摐嵔惗暔妛嫵堢尋媶僙儞僞乕挿
庴徿
1997丂丂丂丂丂JB榑暥徿乮擔杮惗壔妛夛乯

戙昞榑暥
1) Biochemical visualization of cell surface molecular clustering in living cells.
Kotani N, Gu J, Isaji T, Udaka K, Taniguchi N, Honke K.
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7405-9.

2) Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.
Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N.
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6

3) Paranodal junction formation and spermatogenesis require sulfoglycolipids.
Honke K, Hirahara Y, Dupree J, Suzuki K, Popko B, Fukushima K, Fukushima J, Nagasawa T, Yoshida N, Wada Y, Taniguchi N.
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4227-32.

乽恡擜嵶娗嵶朎偺忈奞偲嵞惗夁掱偵偍偗傞嵶朎撪僔僌僫儖偲惗懱枌婡擻偺夝柧乿
帥揷丂揟惗丂乮堛椕妛宯椪彴堛妛晹栧撪暘斿戙幱丒恡憻撪壢妛島嵗丂嫵庼乯

尋媶偺奣梫丗
巺媴懱恡墛傗媫惈恡晄慡側偳偺昦懺傪椪彴揑側尒抧偐傜栤戣傪採婲偟丄暘巕惗暔妛揑偁傞偄偼嵞惗堛妛側偳嵟怴偺庤朄傪梡偄偰尋媶傪恑傔偰偒偨丅偦偺惉壥偵傛傝丄擔杮撪壢妛夛彠椼徿丄擔杮恡憻妛夛戝搰徿丄擔杮摟愅堛妛夛妛夛徿側偳傪庴徿偟偨丅
摿偵嬤擭丄媫惈恡晄慡偺夞暅婜偺擜嵶娗嵞惗偺儊僇僯僘儉偺夝柧傪峴偭偰偍傝丄壓婰偺條側悽奅偵愭嬱偗偨尋媶惉壥傪忋偘偰偄傞丅Notch-Delta宯偼嵶朎嬌惈偺曐帩偵廳梫側摥偒偑偁傞帠偑恄宱宯偺敪惗摍偱抦傜傟偰偍傝丄擜嵶娗嵶朎偱偺嵶朎枌忋偺暘巕娫僱僢僩儚乕僋偍傛傃嵶朎枌偲妀撪堚揱巕敪尰偺僔僌僫儖揱払婡峔偺夝柧偼丄媫惈恡晄慡偺昦懺夝柧偵杮幙揑側堄媊傪帩偪丄媫惈恡晄慡偺怴婯偺帯椕朄偺夝柧偵捈寢偡傞尋媶惉壥偑婜懸偱偒傞丅

1) 撪場惈偺恡擜嵶娗姴嵶朎偲亀dedifferentiation亁丅
怽惪幰傜偼丄媫惈恡晄慡偺夞暅婜偵恡戀惗婜偵敪尰偡傞堚揱巕丄Wnt4偍傛傃Notch-Delta宯偑擜嵶娗嵶朎偵嵞敪尰偟丄戀惗婜偺姴嵶朎揑側惈奿傪傕偮丄憹怋擻偑崅偄嵶朎偑嬤埵擜嵶娗偵敪尰偡傞偙偲傪悽奅偵愭嬱偗偰尒偄偩偟丄擜嵶娗偺亀dedifferentiation亁偲偄偆奣擮傪採彞偟偨丅偙偺亀dedifferentiation亁偲偄偆奣擮偼傾儊儕僇恡憻妛夛帍偺憤愢亀媫惈恡晄慡偺嵟怴偺儊僇僯僘儉亁(Devarajan P: Update on Mechanisms of Ischemic Acute Renal Injury, J Am Soc Nephrol, 17, 1503-1530, 2006) 偵傕庢傝忋偘傜傟丄擣抦偝傟偰偄傞丅

2) 恡嵞惗場巕乮堚揱巕乯傪梡偄偨恡嵞惗尋媶偺敪揥惈
怽惪幰偼恡戀惗婜偺Key Molecule偺岓曗偲偟偰丄Wnt4, Notch2埲奜偵Wnt11傗Sall1偵拲栚偟偰偄傞丅偙傟傜偺堚揱巕傪恡擜嵶娗偵堚揱巕摫擖偟偰擜嵶娗嵶朎偑丄嵞惗偟憹怋丄廋暅偱偒傞旝彫娐嫬(Microenviroment)偁傞偄偼嵞惗偺応乮Niche乯傪嶌傝弌偡帠偵傛傝丄怴婯偺帯椕朄偵偮側偑傞壜擻惈偑偁傝丄旕忢偵撈憂揑偱偁傞丅

3) iPS嵶朎乮ES嵶朎乯傪梡偄偨恡嵞惗尋媶
iPS嵶朎乮ES嵶朎乯偐傜偼丄恡嵶朎傊偺暘壔偺帋傒偼枹偩側偄丅怽惪幰傜偼丄儅僂僗ES嵶朎傪EB(embrioid body)嵶朎偵暘壔偝偣傞嵺丄Wnt-4堚揱巕傪埨掕敪尰偡傞ES 嵶朎傪妋棫偟丄HGF偍傛傃丄Activin傪揧壛偡傞偲悈僠儍僱儖(Aquaporin 2)傪敪尰偟丄擜嵶娗條峔憿傪偲傞偙偲傪曬崘偟丄悽奅偱弶傔偰ES嵶朎偐傜恡嵶朎傊偺暘壔桿摫偵惉岟偟偨丅偝傜偵丄僸僩娫梩宯姴嵶朎傪儅僂僗戀帣恡撪偵堏怉偟偰丄恡峔惉嵶朎偵暘壔偡傞偙偲傪暷崙傾僇僨儈乕婭梫偵曬崘偟偨丅

帥揷丂揟惗乮偰傜偩丂傛偟偍乯

戙昞榑暥
1) Terada Y, Tomita K, Nonoguchi H, Yang T, Marumo F: Different localization and r egulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction. J Clin Invest 92: 2339-2345, 1993

2) Terada Y, Tomita K, Homma MK, Nonoguchi H, Yang T, Yamada T, Yuasa Y, Krebs EG, Marumo F: Sequential activation of raf-1 kinase, MAP kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cell. J Biol Chem 269: 31296-31301, 1994

3) Taniguchi K, Kohsaka H, Inoue N, Terada Y, Ito H, Hirokawa K, Miyasaka N: Introduction of p16INK4a sequence gene as a novel therapeutic strategy for the treatment of rheumatoid arthritis. Nature Med 5: 760-767, 1999

乽僶儕傾攋抅偵偍偗傞昞旂嵶朎柶塽嵶朎娫僋儘僗僩乕僋偺曄挷儊僇僯僘儉偺夝柧乿
嵅栰 塰婭乮堛椕妛宯椪彴堛妛晹栧旂晢壢妛島嵗丂嫵庼乯

尋媶偺奣梫
昞旂僶儕傾偼妏憌偵懚嵼偟丄僴僾僥儞側偳傪娷傓壔妛暔幙偺燌摟傪杊偖偨傔偺婡峔偱偁傞丅僶儕傾偺攋抅偼憕攋丄奅柺妶惈嵻側偳偺婡夿揑丒暔棟揑巋寖偵傛偭偰堷偒婲偙偝傟傞丅傾僩僺乕惈旂晢墛(AD)傗姡釢側偳枬惈旂晢墛徢惈幘姵偱僶儕傾偺攋抅偑擣傔傜傟傞丅嵟嬤丄AD偺妏幙偱偼旂晢僶儕傾偵昁梫側僙儔儈僪偑尭彮偟偰偄傞偙偲傕柧傜偐偵偝傟偨丅偝傜偵丄僼傿儔僌儕儞偺堚揱巕曄堎偑崅棪偵傾僩僺乕惈旂晢墛丄婥娗巟歜懅偱傕擣傔傜傟傞偙偲偑曬崘偝傟偨丅僼傿儔僌儕儞偼妏憌偵偍偄偰僶儕傾婡擻偵廳梫側抈敀偱偁傞偙偲傛傝丄AD偺敪徢偵旂晢僶儕傾攋抅偑娭梌偟偰偄傞偙偲偑堦憌柧傜偐偵側偭偰偒偨丅偙偺傛偆偵丄昞旂僶儕傾婡擻偺攋抅偑僴僾僥儞峈尨偺摟夁傪梕堈偵偡傞偨傔丄偦傟偵懳偡傞姶嶌偑惉棫偟傗偡偔側傞丅偙偺傛偆偵丄傾儗儖僊乕儕僗僋偼僶儕傾攋抅偵傛傝憹戝偡傞偲峫偊傜傟傞丅偟偐偟丄僶儕傾攋抅偺傒偑旂晢柶塽偵捈愙偳偺傛偆側塭嬁傪梌偊傞偐偵偮偄偰偼偄傑偩晄柧偱偁傞丅変乆偼丄僙儔儈僪崌惉峺慺偺堚揱巕乮sptlc2乯傪昞旂嵶朎摿堎揑偵僲僢僋傾僂僩(cKO)偡傞偙偲偵惉岟偟偨丅偙偺儅僂僗偱偼僶儕傾廋暅抶墑丄昞旂嵶朎偺墛徢僔僌僫儖偑敪尰偟丄偦偺屻旂晢墛傪帺慠偵敪徢偡傞偙偲傪柧傜偐偵偟偨丅摨帪偵丄旂晢偺儔儞僎儖僴儞僗嵶朎偺妶惈壔偲旂晢偍傛傃強懏儕儞僷愡偺Th17嵶朎偺憹怋傪擣傔偨丅偙偺寢壥偼丄昞旂僶儕傾偺攋抅僔僌僫儖偑旂晢屌桳偺柶塽宯偲偺僋儘僗僩乕僋傪帵嵈偟偰偄傞丅尰嵼丄暘巕儗儀儖偱偺徻嵶側儊僇僯僘儉偵偮偒夝愅拞偱偁傞丅

嵅栰丂塰婭乮偝偺丂偟偘偲偟乯

妛楌
徍榓58擭  3寧丂垽昋戝妛堛妛晹堛妛壢懖嬈
徍榓63擭  3寧丂戝嶃戝妛戝妛堾攷巑壽掱乮堛妛乯廋椆
怑楌
徍榓58擭  7寧丂堛堳乮尋廋堛乯乮戝嶃戝妛堛妛晹晬懏昦堾旂晢壢乯
徍榓59擭  3寧丂摨丂廋椆
徍榓63擭  7寧丂堛堳乮戝嶃戝妛堛妛晹晬懏昦堾旂晢壢乯
徍榓63擭12寧丂Research fellow乮USA, Albert Einstein Medical College柶塽旝惗暔妛乯
暯惉  4擭  4寧丂巗棫嶄昦堾旂晢壢堛挿
暯惉  6擭12寧丂戝嶃戝妛堛妛晹旂晢壢妛島嵗彆庤
暯惉11擭  1寧丂戝嶃戝妛戝妛堾堛妛宯尋媶壢島巘乮旂晢壢妛島嵗乯
暯惉15擭  6寧丂Assistant professor乮USA, MD Anderson Cancer Center乯
暯惉16擭  9寧丂嵿抍朄恖廧桭昦堾旂晢壢晹挿乮暯惉17擭10寧傑偱乯
暯惉17擭11寧丂戝嶃戝妛戝妛堾堛妛尋媶壢島巘乮旂晢壢妛乯
暯惉18擭  5寧丂戝嶃戝妛戝妛堾堛妛尋媶壢彆嫵庼乮旂晢壢妛乯
暯惉19擭  4寧丂崙棫戝妛朄恖崅抦戝妛堛妛晹旂晢壢妛島嵗嫵庼

戙昞榑暥
1) Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. Sano S, Chan KS, DiGiovanni J.
J Dermatol Sci. 2008 Apr;50(1):1-14.

2) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J.
Nat Med. 2005 Jan;11(1):43-9.

3) Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H, Yoshikawa K, Akira S, Takeda J. EMBO J. 1999 Sep 1;18(17):4657-68.

乽旕東栿RNA偵傛傞嵶朎撪僔僌僫儖揱払偺惂屼乿丂
嶁杮丂廋巑 乮憤崌尋媶僙儞僞乕丒暘巕惗暔妛嫵幒 彆嫵乯

尋媶偺奣梫
儅僀僋儘RNA (miRNA)偼旕東栿惈偺彫暘巕RNA偱丄恀妀惗暔偵偍偗傞堚揱巕敪尰偺挷愡場巕偲偟偰婡擻偡傞丅偦偺婡擻揑側廳梫惈偼丄嵶朎偺憹怋丄暘壔丄傾億僩乕僔僗偱妋擣偝傟偰偄傞丅嬤擭丄変乆偼丄妀撪擇杮嵔RNA寢崌抈敀幙偱偁傞Nuclear Factor 90 (NF90)偲偦偺寢崌僷乕僩僫乕偱偁傞NF45偺暋崌懱(NF90-NF45)偑丄miRNA偺惗崌惉宱楬偵偍偄偰晧偺挷愡場巕偲偟偰婡擻偡傞偙偲傪尒弌偟偨(MCB 2009 29 (13) 3754-69)丅偙偺敪尒偼丄偙傟傜偺抈敀幙偑丄miRNA惗崌惉偺挷愡場巕偲偟偰偺婡擻傪捠偠偰丄條乆側惗懱惂屼婡峔偵娭梌偡傞壜擻惈傪帵嵈偟偰偄傞丅偦偙偱変乆偼丄偙偺偙偲傪専徹偡傞偨傔偵丄慡恎惈偵NF90-NF45傪夁忚敪尰偟偨(Tg)儅僂僗傪嶌弌偟丄昞尰宆傪夝愅偡傞偙偲傪栚巜偟偰偄傞丅偦傟偵愭棫偪丄婛偵NF90媦傃NF45偺Tg儅僂僗偼嶌惢嵪傒偱丄尰嵼丄椉Tg儅僂僗傪妡偗崌傢偣NF90-NF45 Tg儅僂僗偺嶌弌傪帋傒偰偄傞丅摨帪偵NF90媦傃NF45奺乆偺Tg儅僂僗偺昞尰宆傪夝愅偟丄偙傟傑偱偵丄NF90 Tg儅僂僗偵偍偄偰嫽枴怺偄尰徾傪尒弌偟偨丅偙偺儅僂僗偺嵟傕摿挜揑側昞尰宆偲偟偰懱偺彫偝偝偑嫇偘傜傟傞丅偦偺梫場傪扵傞傋偔丄慻怐妛揑夝愅傪恑傔偨寢壥丄NF90偑夁忚敪尰偟偰偄傞怱嬝傗崪奿嬝偱偼丄儈僩僐儞僪儕傾偑扙棊偟丄懡偔偺嬻朎曄惈偑惗偠偰偄傞偙偲偑傢偐偭偨丅傑偨惗棟妛揑丄暘巕惗暔妛揑丄宍懺妛揑夝愅偵傛傝丄偙偺儅僂僗偼怱晄慡傪敪徢偟偰偍傝丄偝傜偵戝戁巐摢嬝丄銫暊嬝丄慜泺崪嬝摍偺嬝検偑尠挊偵掅壓偟偰偄傞偙偲偑柧傜偐偲側偭偨丅廬偭偰丄NF90 Tg儅僂僗偺懱偺彫偝偝偼丄儈僩僐儞僪儕傾曄惈偵傛傞嬝慻怐偺宍惉堎忢偵傛傞傕偺偱偁傞偙偲偑傢偐偭偰偒偨丅偦偙偱尰嵼偼丄嬝慻怐偵偍偗傞NF90偵傛傞儈僩僐儞僪儕傾曄惈偺儊僇僯僘儉傪夝柧偡傞偨傔偵丄摿偵NF90偵傛偭偰敪尰偑惂屼偝傟偰偄傞miRNA偑娭梌偡傞嵶朎撪僔僌僫儖揱払婡峔偵拝栚偟夝愅傪恑傔偰偄傞丅

嶁杮丂廋巑 乮偝偐傕偲丂偟傘偆偠乯

戙昞榑暥
1) The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway.
Sakamoto S, Aoki K, Higuchi T, Todaka H, Morisawa K, Tamaki N, Hatano E, Fukushima A, Taniguchi T, Agata Y.
Mol Cell Biol. 2009 Jul;29(13):3754-69.

2) Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes.
Sakamoto S, Potla R, Larner AC.
J Biol Chem. 2004 Sep 24;279(39):40362-7.

3) Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naive cells.
Sakamoto S, Qin J, Navarro A, Gamero A, Potla R, Yi T, Zhu W, Baker DP, Feldman G, Larner AC.
J Biol Chem. 2004 Jan 30;279(5):3245-53.

乽儂儎偺恄宱娗宍惉傪惂屼偡傞嵶朎撪奜偺僔僌僫儖岎姺儊僇僯僘儉偺夝柧乿
摗尨 帬庽乮帺慠壢妛宯棟妛晹栧丂嫵庼乯

尋媶偺奣梫
儂儎偺梒惗偼嵶朎悢傢偢偐2500屄偱偁傝側偑傜丆愐嶕摦暔偺婎杮揑側懱惂傪旛偊偰偄傞丅偦偺偨傔丆愐嶕摦暔偺懱惂傪峔抸偡傞巇慻傒偲偦偺恑壔傪尋媶偡傞偨傔偺儌僨儖摦暔偲偟偰廳梫偱偁傞丅杮尋媶偼丆愐嶕摦暔摿桳偺婍姱偲偟偰丆攚懁偵惗偠傞恄宱娗偵拲栚偟丆恄宱娗宍惉傪惂屼偡傞嵶朎憹怋場巕傗嵶朎奜儅僩儕僢僋僗側偳偺嵶朎奜場巕偲丆揮幨挷愡場巕側偳偺嵶朎撪場巕偲偺憡屳嶌梡偺巇慻傒偺夝柧傪栚巜偡丅
巹偨偪偼丆偙傟傑偱偵嵶朎憹怋場巕Nodal偑丆揮幨場巕Cdx偺婡擻傪夘偟偰恄宱娗宍惉偵娭梌偡傞偙偲傪柧傜偐偵偟偨丅傑偨丆儅僀僋儘傾儗僀夝愅偵傛偭偰Nodal偺昗揑堚揱巕傪懡悢摨掕偟偨丅偦偺拞偵偼丆嵶朎奜儅僩儕僢僋僗暘巕傗嵶朎愙拝暘巕丆傑偨嵶朎偺嬌惈傗宍懺曄壔傪惂屼偡傞嵶朎撪場巕傪僐乕僪偡傞堚揱巕偑懡悢敪尒偝傟偨丅偙傟偲偼暿偵丆巹偨偪偼嵶朎奜儅僩儕僢僋僗偺庡梫惉暘偱偁傞僾儘僥僆僌儕僇儞偺摐嵔崌惉偁傞偄偼摐嵔廋忺偵娭梌偡傞偄偔偮偐偺堚揱巕偑恄宱娗傗偦傟偵椬愙偡傞愐嶕偱摿堎揑偵敪尰偡傞偙偲傪敪尒偟偨丅杮尋媶偱偼偙傟傜偺堚揱巕偺婡擻夝愅傪峴偄丆恄宱娗宍惉偵偍偗傞嵶朎塣摦惂屼偺儊僇僯僘儉夝柧傪栚巜偡丅摿偵丆嵶朎枌忋偺庴梕懱傗愙拝暘巕側偳傪夘偟偰丆嵶朎奜偺僔僌僫儖偲嵶朎撪偺場巕偲偺憡屳嶌梡偑偄偐偵偟偰峴傢傟偰偄傞偐傪夝柧偟偨偄丅

摗尨 帬庽乮傆偠傢傜丂偟偘偒乯

妛楌丒怑楌
1987乮徍榓62乯擭丂嫗搒戝妛棟妛晹懖嬈乮惗暔妛乯
1989乮暯惉尦乯擭丂嫗搒戝妛戝妛堾棟妛尋媶壢廋巑壽掱廋椆乮摦暔妛乯
1989乮暯惉尦乯擭丂嫗搒戝妛戝妛堾棟妛尋媶壢攷巑屻婜壽掱擖妛乮摦暔妛乯
1990乮暯惉2乯擭丂嫗搒戝妛戝妛堾棟妛尋媶壢戅妛亅崅抦戝妛棟妛晹惗暔妛嫵幒彆庤
1997乮暯惉9乯乣1998乮暯惉10乯擭丂僇儕僼僅儖僯傾戝妛僶乕僋儗乕峑尋媶堳
1999乮暯惉11乯擭丂崅抦戝妛棟妛晹暔幙壢妛壢彆嫵庼
2006乮暯惉18乯擭丂崅抦戝妛棟妛晹暔幙壢妛壢嫵庼
2008乮暯惉20乯擭丂崅抦戝妛嫵堢尋媶晹帺慠壢妛宯乮棟妛晹栧乯嫵庼
2010乮暯惉22乯擭丂崅抦戝妛憤崌尋媶僙儞僞乕乮奀梞惗暔妛晹栧乯寭擟嫵庼
尰嵼偵帄傞

3) Retinoids and nonvertebrate chordate development.
Fujiwara S.
J Neurobiol. 2006 Jun; 66(7): 645-52. Review.? PMID: 16688759

乽尨惗摦暔偺懴惈僔僗僩宍惉傪桿摫偡傞僔僌僫儖揱払宯偺夝柧乿
徏壀 払恇乮帺慠壢妛宯棟妛晹栧摦暔惗棟妛尋媶幒丂嫵庼乯

尋媶偺奣梫
尨惗摦暔偺懴惈媥柊僔僗僩宍惉偲扙僔僗僩乮敪夎乯偺暘巕婡峔偺夝柧偼丄乽嵶朎峔憿偺峔抸婡峔偺夝柧乿偲偄偆嵶朎惗暔妛揑側堄媊偩偗偱側偔丄懴惈僔僗僩傪宍惉偡傞昦尨惈尨惗摦暔偵傛傞姶愼徢偺帯椕傪帇栰偵偄傟偨婎斦尋媶偲偟偰傕廳梫偱偡丅巹偨偪偼丄搚忞惈尨惗摦暔偱偁傞僐儖億乕僟乮Colpoda cucullus乯偺懴惈媥柊僔僗僩宍惉偲扙僔僗僩偺嵶朎撪忣曬揱払婡峔偺夝柧傪栚巜偟偰尋媶傪恑傔偰偒傑偟偨丅偙偺寢壥丄僔僗僩宍惉偺忣曬揱払宯偑僇儖僔僂儉僀僆儞偵傛偭偰妶惈壔偝傟傞偙偲丄偦偺宱楬偺壓棳偵偍偄偰cAMP/僞儞僷僋僉僫乕僛A乮PKA乯埶懚揑偵傾僋僠儞傗儕儃僜乕儉S5僞儞僷僋幙側偳偺儕儞巁壔儗儀儖偺忋徃偑偍偒傞偙偲側偳傪敪尒偟傑偟偨丅偝傜偵丄僞儞僷僋幙偺儕儞巁壔偵懕偄偰丄ATP僔儞僞乕僛兝嵔丄僸乕僩僔儑僢僋僞儞僷僋幙側偳偺暋悢偺僞儞僷僋幙偺敪尰儗儀儖偑戝偒偔曄壔偡傞偙偲傕柧傜偐偵側偭偰偒傑偟偨丅偙傟傜偺寢壥偐傜丄昦尨惈偺桳柍偵娭學側偔尨惗摦暔偺庬傪挻偊偨嫟捠偺僔僗僩宍惉偺偟偔傒偑懚嵼偡傞偙偲偑悇嶡偝傟傑偡丅尰嵼偼丄Feeding RNAi僲僢僋僟僂儞朄傪梡偄偰丄偙傟傜偺僞儞僷僋幙偺敪尰傪梷惂偡傞偙偲偵傛傝丄僔僗僩宍惉偵偍偗傞婡擻夝柧傪栚巜偟偰偄傑偡丅

徏壀 払恇乮傑偮偍偐丂偨偮偍傒乯

妛楌
1979擭丂崅抦戝妛暥棟妛晹懖嬈
1985擭丂峀搰戝妛戝妛堾棟妛尋媶壢攷巑壽掱扨埵庢摼戅妛
1986擭丂棟妛攷巑乮拀攇戝妛乯
怑楌
1986擭丂傾儖僶乕僩傾僀儞僔儏僞僀儞堛壢戝妛尋媶堳
1988擭丂崅抦戝妛棟妛晹彆庤
1992擭丂摨彆嫵庼
1999擭丂摨嫵庼
庴徿
2000擭丂擔杮尨惗摦暔妛夛徿

戙昞榑暥
1) Blepharismin 1-5, novel photoreceptor from the unicellular organism Blepharisma japonicum.
Maeda M, Naoki H, Matsuoka T, Kato Y, Kotsuki H, Utsumi K, Tanaka T.
Tetrahedron Lett. 1997, 38: 7411-7414

2) Protein phosphorylation in encystment-induced Colpoda cucullus: Localization and identification of phosphoproteins.
Sogame Y, Kojima K, Takeshita T, Fujiwara S, Miyata S, Kinoshita E, Matsuoka T.
FEMS Microbiol. Lett. 2012, 331: 128-135.

3) EF-1a and mitochondrial ATP synthase b chain: alteration of their expression in encystment-induced Colpoda cucullus.
Sogame Y., Kojima K., Takeshita T., Kinoshita E., Matsuoka T.
J. Euk. Microbiol. 2012, 59: 401-406

乽姶愼僂僀儖僗堚揱巕傪敪尰曄壔偝偣傞嵶朎枌暘巕偲偦偺僔僌僫儖揱払偺夝柧乿
戝敤丂夒揟丂乮堛椕妛宯婎慴堛妛晹栧旝惗暔妛島嵗丂嫵庼乯

尋媶奣梫
僿儖儁僗僂僀儖僗偵戙昞偝傟傞傛偆偵丄偁傞庬偺僂僀儖僗偼姶愼屻愽暁姶愼偁傞偄偼帩懕姶愼偺忬懺偱挿偔懱撪偵棷傑傝丄帪偵條乆側巋寖偵傛偭偰嵞妶惈壔傪婲偙偡丅偦偺乽愽暁姶愼乿偲乽嵞妶惈壔乿偺儊僇僯僘儉傪夝柧偡傞偙偲偼丄姶愼徢惂屼偺娤揰偐傜傕嬌傔偰廳梫偱偁傞丅堦曽丄庮釃僂僀儖僗偱傕偁傞EB僂僀儖僗(EBV)側偳偼丄廻庡嵶朎枌忋偵帺傜偺抈敀傪敪尰偝偣丄偦傟偵傛傝嵶朎憹怋傪傕偨傜偡僔僌僫儖揱払傪惗傒弌偟偰偄傞丅
杮僾儘僕僃僋僩偱偼丄EBV傪拞怱偲偟偰丄僂僀儖僗嵞妶惈壔偵婑梌偡傞嵶朎枌忋偺僔僌僫儖暘巕偺扵媶丄偍傛傃嵶朎枌偐傜妀撪堚揱巕敪尰傊偲帄傞僔僌僫儖揱払婡峔偺夝柧傪栚巜偡丅偝傜偵旝惗暔姶愼偑嵶朎枌忋偺偳偺傛偆側暘巕偵塭嬁傪梌偊傞偺偐傪柧傜偐偵偟偨偄丅

妛楌丒怑楌
1985擭丂丂丂丂丂 崅抦堛壢戝妛乮尰崅抦戝妛堛妛晹乯懖嬈
1989擭丂丂丂丂丂 崅抦堛壢戝妛戝妛堾攷巑壽掱廋椆乮堛妛攷巑乯
1989乣1994擭丂丂暷崙儅僒僠儏乕僙僢僣堛壢戝妛丂Instructor
1994乣2000擭丂丂崅抦堛壢戝妛暥晹嫵姱彆庤乮戞嶰撪壢)
2000乣2003擭丂丂崅抦堛壢戝妛 寣塼丒屇媧婍撪壢乮戞嶰撪壢乯島巘
2003乣2007擭丂丂崅抦戝妛堛妛晹 寣塼丒屇媧婍撪壢乮戞嶰撪壢乯島巘
2007乣2009擭丂丂崅抦戝妛堛妛晹 寣塼丒屇媧婍撪壢乮戞嶰撪壢乯弝嫵庼
2009擭乣丂丂丂丂 崅抦戝妛堛妛晹 旝惗暔妛島嵗丂嫵庼丂丂尰嵼偵帄傞丂
妛夛帒奿
擔杮撪壢妛夛擣掕憤崌撪壢愱栧堛丒巜摫堛
擔杮寣塼妛夛擣掕寣塼愱栧堛丒巜摫堛
擔杮姶愼徢妛夛擣掕姶愼徢愱栧堛
擔杮屇媧婍妛夛擣掕屇媧婍愱栧堛
ICD惂搙嫤媍夛僀儞僼僃僋僔儑儞僐儞僩儘乕儖僪僋僞乕
擔杮偑傫帯椕擣掕堛婡峔 偑傫帯椕擣掕堛
庴徿
2000擭丂擔杮娻妛夛丂彠椼徿

戙昞榑暥
1) Hashida Y, Imajoh M, Nemoto Y, Kamioka M, Taniguchi A, Taguchi T, Kume M, Orihashi K, Daibata M. Detection of Merkel cell polyomavirus with a tumour-specific signature in non-small-cell lung cancer. Br J Cancer. 108: 629-637, 2013.

2) Daibata M, Nemoto Y, Bandobashi K, Kotani N, Kuroda M, Tsuchiya M, Okuda H, Takakuwa T, Imai S, Shuin T, Taguchi H. Promoter hypermethylation of the bone morphogenetic protein-6 gene in malignant lymphoma. Clin Cancer Res. 13: 3528-3535, 2007.

3) Daibata M, Bandobashi K, Kuroda M, Imai S, Miyoshi I, Taguchi H. Induction of lytic Epstein-Barr virus (EBV) infection by synergistic action of rituximab and dexamethasone renders EBV-positive lymphoma cells more susceptible to ganciclovir cytotoxicity in vitro and in vivo. J Virol. 79: 5875-5879, 2005.

4) Daibata M, Taguchi T, Nemoto Y, Taguchi H, Miyoshi I. Inheritance of chromosomally integrated human herpesvirus 6 DNA. Blood. 94: 1545-1549, 1999.

5) Daibata M, Taguchi T, Sawada T, Taguchi T, Miyoshi I. Chromosomal transmission of human herpesvirus 6 DNA in acute lymphoblastic leukaemia. Lancet. 352: 543-544, 1998.

乽嘆堚揱巕慻姺偊儅僂僗偺嶌惢偲夝愅偺巟墖
丂嘇僀儊乕僕儞僌憰抲乮MRI丄寀岝僀儊乕僕儞僌乯傪梡偄偨in vivo夝愅媄弍偺奐敪乿
捗揷丂夒擵乮憤崌尋媶僙儞僞乕惗柦丒婡擻暔幙晹栧摦暔帒尮奐敪暘栰丂弝嫵庼乯

尋媶偺奣梫
嘆堚揱巕慻姺偊儅僂僗偺嶌惢偲夝愅偺巟墖
尰嵼丄惗柦壢妛偺暘栰偱偼堚揱巕慻姺偊儅僂僗傪梡偄偨in vivo偱偺夝愅偑昁梫晄壜寚偱偁傞丅摦暔帒尮奐敪暘栰偱偼丄奺尋媶斍偑夝愅偟偰偄傞暘巕傗怴婯暘巕偵娭楢偡傞峈懱傗堚揱慻姺偊儅僂僗偺嶌惢傪峴偭偰偄傞丅傑偨丄枌娫憡屳嶌梡傗僔僌僫儖揱払偵娭梌偡傞暘巕偺摦懺傗憡屳嶌梡傪惗懱撪偱壜帇壔偱偒傞傛偆側堚揱巕傪慻姺偊儅僂僗傪嶌惢偡傞側偳丄怴偟偄僣乕儖偺奐敪傕峴偭偰偄傞丅

嘇僀儊乕僕儞僌憰抲乮MRI丄寀岝僀儊乕僕儞僌乯傪梡偄偨in vivo夝愅媄弍偺奐敪
偝傑偞傑幚尡摦暔梡偺僀儊乕僕儞僌憰抲偑奐敪偝傟丄惗偒偨傑傑偺摦暔傪旕怤廝揑偵娤嶡偱偒傞傛偆偵側偭偰偒偨丅摦暔幚尡巤愝偵偼丄寀岝僀儊乕僕儞僌憰抲傗崅帴応MRI偑摫擖偝傟丄惗懱撪偵偍偗傞暘巕偺暘晍丒摦懺傪夝愅偡傞偙偲偑壜擻偲側偭偨丅摦暔帒尮奐敪暘栰偱偼偙傟傜偺憰抲傪梡偄偰丄惗懱枌婡擻偺夝柧偵偮側偘傞偲偲傕偵丄怴偟偄僀儊乕僕儞僌媄弍偺奐敪傪峴偭偰偄傞丅

戙昞榑暥
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