尋媶嬈愌
<俀侽俀係擭搙>Cutibacterium acnes invades prostate epithelial cells to induce BRCAness as a possible pathogen of prostate cancer
Ashida S, Kawada C, Tanaka H, Kurabayashi A, Yagyu KI, Sakamoto S, Maejima K, Miyano S, Daibata M, Nakagawa H, Inoue K.
The Prostate. 84(11):1056-1066. (2024)
Depth of Interbreed Difference in Postmortem Bovine Muscle Determined by CE-FT/MS and LC-FT/MS Metabolomics
Susumu Muroya, Yuta Horiuchi, Kazuki Iguchi, Takuma Higuchi, Shuji Sakamoto, Koichi Ojima, Kazutsugu Matsukawa
Metabolites. 14(5):261. (2024)
<俀侽俀俁擭搙>
Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis
Ken-ichi Matsumoto(Co-corresponding author), Takuma Higuchi, Mirei Umeki, Masafumi Ono, Shuji Sakamoto (Co-corresponding author)
Biomedical Research (Tokyo). 45(2):67-76. (2024)
<俀侽俀俀擭搙>
NF90-NF45 is essential for 兝 cell compensation under obesity-inducing metabolic stress through suppression of p53 signaling pathway
Sylvia Lai, Takuma Higuchi, Masayuki Tsuda, Yasunori Sugiyama, Keiko Morisawa, Taketoshi Taniguchi, Shuji Sakamoto (Corresponding author)
Scientific Reports. 12(1):8837. (2022)
Heterogeneous IgE reactivities to Staphylococcus pseudintermedius strains in dogs with atopic dermatitis and the identification of DM13-domain-containing protein as a bacterial IgE-reactive molecule
Iyo Takemura-Uchiyama, Hiroki Tsurui, Hidekatsu Shimakura, Tadahiro Nasukawa, Ichiro Imanishi, Jumpei Uchiyama, Tomoki Fukuyama, Shuji Sakamoto, Keiko Morisawa, Masato Fujimura, Hironobu Murakami, Shuji Kanamaru, Kenji Kurokawa, Keiko Kawamoto, Keita Iyori, Masahiro Sakaguchi.
FEMS Microbiology Letters. 369: 1-7. (2022)
<俀侽俀1擭擭搙>
俀宆摐擜昦偵偍偄偰僀儞僗儕儞敪尰梷惂傪惂屼偡傞怴婯僔僌僫儖宱楬夝
悪嶳 峃寷丄拞崻 払恖丄嶁杮 廋巑丄懞旜 岶帣
揹婥塲摦, 65:47-50 (2021)
擇杮嵔RNA寢崌僞儞僷僋幙偑寢崌偡傞儅僀僋儘RNA弶婜揮幨嶻暔偺峔憿揑摿挜偺夝愅
旙岥 琢杹, Rosemary Kiernan(Co-coorresponding author), 嶁杮 廋巑 (Co-corresponding author)
揹婥塲摦, 65(1):13-16 (2021)
YAF2-mediated YY1-Sirtuin6 interactions responsible formitochondrial down-regulation in aging tunicates
Kaz Kawamura , Takuma Higuchi , Shigeki Fujiwara
Mol. Cell. Biol., 41(7):e0004721.
<俀侽俀侽擭搙>
NF90 Modulates Processing of a Subset of Human Pri-miRNAs
Giuseppa Grasso, Takuma Higuchi, Victor Mac, Jérôme Barbier, Marion Helsmoortel, Claudio Lorenzi, Gabriel Sanchez, Maxime Bello, William Ritchie, Shuji Sakamoto, Rosemary Kiernan
Nucleic Acids Res., 48(12):6874-6888 (2020)
<俀侽侾9擭搙>
Candidate plasticity gene 16 mediates suppression of insulin gene expression in rat insulinoma INS-1 cells under glucotoxic conditions
Tatsuto Nakane, Ayae Ido, Takuma Higuchi, Hiroshi Todaka, Keiko Morisawa, Tadashi Nagamine, Kensaku Fukunaga, Shuji Sakamoto, Yasunori Sugiyama
Biochem. Biophys. Res. Commun., 512(2), 189-195 (2019)
<俀侽侾俉擭搙>
A negative feedback loop between Nuclear Factor 90 (NF90) and an anti-oncogenic microRNA, miR-7
Takuma Higuchi, Keiko Morisawa, Hiroshi Todaka, Sylvia Lai, Eunsup Chi, Kazutsugu Matsukawa, Yasunori Sugiyama, Shuji Sakamoto (Corresponding author)
Biochem. Biophys. Res. Commun., 503(3), 1819-1824 (2018)
A method for profiling the phosphorylation state of tyrosine protein kinases
Yuuki Uezato, Isamu Kameshita, Keiko Morisawa, Shuji Sakamoto, Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike, Yasunori Sugiyama
Biochim. Biophys. Acta., 1867(1), 71-75 (2018)
An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression
Jérôme Barbier, Xin Chen, Gabriel Sanchez, Muyan Cai, Marion Helsmoortel, Takuma Higuchi, Pierre Giraud, Xavier Contreras, Gangjun Yuan, Zihao Feng, Rima Nait-Saidi, Olivier Deas, Lisa Bluy, Jean-Gabriel Judde, Sylvie Rouquier, William Ritchie, Shuji Sakamoto, Dan Xie & Rosemary Kiernan
Cell Research, 28(5):556-571 (2018)
<俀侽侾6擭搙>
microRNA 惗崌惉偑堷偒婲偙偡昦懺惗棟尰徾
屗崅 姲, 旙岥 戶杹, 嶁杮 廋巑 (Corresponding author)
斾妑惗棟妛, Vol. 34, No. 4, 183-190 (2016)
Suppression of miR-7 biogenesis by NF90-NF45 controls cell proliferation in hepatocellular carcinoma
Takuma Higuchi, Hiroshi Todaka, Yasunori Sugiyama, Masafumi Ono, Nobuyuki Tamaki, Etsuro Hatano, Yuka Takezaki, Takeshi Miwa, Sylvia Lai, Keiko Morisawa, Masayuki Tsuda, Taketoshi Taniguchi, Shuji Sakamoto (Corresponding author)
J. Biol. Chem., 291(40), 21074-21084 (2016)
PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice
Tsunehiro Ochi, Kensuke Munekage, Masafumi Ono, Takuma Higuchi, Masayuki Tsuda, Yoshihiro Hayashi, Nobuto Okamoto, Katsumi Toda, Shuji Sakamoto, Jude A Oben, Toshiji Saibara
Hepatology Res., 46(6), 584-592 (2016)
<俀侽侾俆擭搙>
Overexpression of NF90-NF45 represses myogenic microRNA biogenesis, developing skeletal muscle atrophy and centronuclear muscle fibers
Hiroshi Todaka, Takuma Higuchi, Ken-ichi Yagyu, Yasunori Sugiyama, Fumika Yamaguchi, Keiko Morisawa, Masafumi Ono, Atsuki Fukushima, Masayuki Tsuda, Taketoshi Taniguchi, Shuji Sakamoto (Corresponding author)
Mol. Cell. Biol., 35(13), 2295-2308 (2015)
Expression and phosphorylation state analysis of intracellular protein kinases using Multi-PK antibody and Phos-tag SDS-PAGE
Yasunori Sugiyama, Syouichi Katayama, Isamu Kameshita, Keiko Morisawa, Takuma, Higuchi, Hiroshi Todaka, Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike, Taketoshi Taniguchi, Shuji Sakamoto
MethodsX, 2, 469-474 (2015)
儅儖僠PK峈懱偲Phos-tag傪棙梡偟偨嵶朎撪儕儞巁壔摦懺偺怴婯夝愅朄
悪嶳 峃寷, 婽壓 桬, 嶁杮 廋巑
惗暔暔棟壔妛乚揹婥塲摦乚, 59(2), 82-84 (2015)
亙俀侽侾係擭搙亜
Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates
progression of nonalcoholic steatohepatitis in mice
Masafumi Ono, Mitsunari Ogasawara, Akira Hirose, Sachiko Mogami, Nobuhiro Ootake, Kosuke Aritake, Takuma Higuchi, Nobuto Okamoto, Shuji Sakamoto, Masahiro Yamamoto, Yoshihiro Urade, Toshiji Saibara, Jude A. Oben
J. Gastroenterol., 49(6), 1065-1073 (2014)
亙俀侽侾俀擭搙亜
High expression of nuclear factor 90 (NF90) leads to mitochondrial degradation in skeletal and cardiac muscles
Takuma Higuchi, Shuji Sakamoto (Corresponding author), Yoshihiko Kakinuma, Shoko Kai, Ken-ichi Yagyu, Hiroshi Todaka, Eunsup Chi, Shoshiro Okada, Takako Ujihara, Keiko Morisawa, Masafumi Ono, Yasunori Sugiyama, Waka Ishida, Atsuki Fukushima, Masayuki Tsuda, Yasutoshi Agata, Taketoshi Taniguchi
PLoS One, 7, e43340 (2012)
PKL01, an Ndr kinase homologue in plant, shows tyrosine kinase activity
Syouichi Katayama, Yasunori Sugiyama, Naoya Hatano, Toru Terachi, Noriyuki Sueyoshi, Isamu Kameshita
J. Biochem., 152, 347-353 (2012)
E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin k Locus
Shuji Sakamoto, Kousho Wakae, Yuki Anzai, Kiyohito Murai, Nobuyuki Tamaki, Masaki Miyazaki, Kazuko Miyazaki, William J. Romanow, Tomokatsu Ikawa, Daisuke Kitamura, Itaru Yanagihara, Nagahiro Minato, Cornelis Murre, Yasutoshi Agata
J. Immunol., 188, 5547-5560 (2012)
Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin
Eiji Kinoshita, Emiko Kinoshita-Kikuta, Yasunori Sugiyama, Yoshitaka Fukada, Tomomitsu Ozeki, Tohru Koike
Proteomics, 12, 932-937 (2012)
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line
Eiji Takaoka, Hiroshi Sonobe, Kunihiro Akimaru, Shuji Sakamoto, Taro丂Shuin, Masanori Daibata,丂Takahiro Taguchi, Akira Tominaga
Am. J. Cancer Res., 2, 141-152 (2012)
亙俀侽侾侾擭搙亜
Regulation of Experimental Autoimmune Uveoretinitis by Anti-Delta-Like Ligand 4 Monoclonal Antibody
Waka Ishida, Ken Fukuda, Shuji Sakamoto, Noriko Koyama, Akemi Koyanagi, Hideo Yagita, Atsuki Fukushima
Invest. Ophthalmol. Vis. Sci., 52, 8224-8230 (2011)
CoPK32 is a novel stress-responsive protein kinase in the mushroom Coprinopsis cinerea
Keisuke Kaneko, Yasunori Sugiyama, Yusuke Yamada, Noriyuki Sueyoshi, Akira Watanabe, Yasuhiko Asada, Atsuhiko Ishida, Isamu Kaeshita
Biochim. Biophys. Acta., 1810, 620-629 (2011)
Regulation of TCR Vg2 gene rearrangement by the helix-loop-helix protein, E2A
Masatoshi Nozaki, Kousho Wakae, Nobuyuki Tamaki, Shuji Sakamoto, Kiyouhisa Ohnishi, Toshifumi Uejima, Nagahiro Minato, Itaru Yanagihara, Yasutoshi Agata
Int. Immunol., 23, 297-305 (2011)
A novel and comprehensivemousemodel of human non-alcoholic steatohepatitiswith the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet
Mitsunari Ogasawara, Akira Hirose, Masafumi Ono, Kosuke Aritake, Yasuko Nozaki, Masaya Takahashi, Nobuto Okamoto, Shuji Sakamoto, Shinji Iwasaki, Taketoshi Asanuma, Taketoshi Taniguchi, Yoshihiro Urade, Saburo Onishi, Toshiji Saibara, Jude A Oben
Liver Int., 31, 542-551 (2011)
Dynamic Changes of microRNAs in the Eye during the Development of Experimental Autoimmune Uveoretinitis
Waka Ishida, Ken Fukuda, Takuma Higuchi, Mina Kajisako, Shuji Sakamoto, Atsuki Fukushima
Invest. Ophthalmol. Vis. Sci., 52, 611-617 (2011)
Calcium/calmodulin-dependent protein kinase IV involvement in the
pathophysiology of glucotoxicity in rat pancreatic 兝-cells
Yasunori Sugiyama, Koji Murao, Hitomi Imachi, Noriyuki Sueyoshi, Toshihiko Ishida, Isamu Kameshita
Metabolism, 60, 145-153 (2011)
microRNA惗崌惉偵偍偗傞晧偺惂屼
嶁杮 廋巑 (Corresponding author), 旙岥 戶杹, 屗崅 姲
THE LUNG perspectives, 19(3), 96-103乮2011乯
亙俀侽侾侽擭搙亜
The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1兟/兠
Yasunori Sgiyama, Naoya Hatano, Noriyuki Sueyoshi, Isao Suetake, Shoji Tajima, Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike, Isamu Kameshita
Biochem. J., 427, 489-497 (2010)
A minimum size homologue of Ca2+/calmodulin-dependent protein kinase IV naturally occurring in zebrafish
Takaki Nimura, Yasunori Sugiyama, Noriyuki Sueyoshi, Yasushi Shigeri, Atsuhiko Ishida, Isamu Kameshita
J. Biochem., 147, 857-865 (2010)
亙俀侽侽俋擭搙亜
The NF90-NF45 Complex Functions as a Negative Regulator
in the MicroRNA Processing Pathway
Shuji Sakamoto (Corresponding author), Kazuma Aoki, Takuma Higuchi, Hiroshi Todaka, Keiko Morisawa, Nobuyuki Tamaki, Etsuro Hatano, Atsuki Fukushima, Taketoshi Taniguchi, Yasutoshi Agata
Mol. Cell. Biol., 29, 3754-3569 (2009)
Systemic overexpression of IFN-gamma and IL-5 exacerbates early phase reaction and conjunctival eosinophilia, respectively, in experimental allergic conjunctivitis
Ishida W, Tsuru E, Tominaga A, Miyazaki J, Higuchi T, Sakamoto S, Fukushima A.
Br. J. Ophthalmol., 93(12), 1680-1685 (2009)
亙俀侽侽俈擭搙亜
Regulation of T Cell Receptor b gene Rearrengements and Allelic Exclusion by the Helix-Loop-Helix Protein, E47
Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C.
Immunity, 27, 871-884 (2007)
亙俀侽侽俇擭搙亜
Type I interferons activate apoptosis in a Jurkat cell variant by caspase-dependent and independent mechanisms
Gamero A, Potla R, Sakamoto S, Baker DP, Abraham R, Larner AC.
Cellular Signalling, 18(8),1299-1308 (2006)
亙俀侽侽係擭搙亜
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in dsRNA-signaling
Sarker SN, Peter KL, Elico CP, Sakamoto S, Pal S, Sen GC.
Nature Structural & Molecular Biology, 11 (11), 1060-1067 (2004)
Histone Deacetylase Activity is Required to Recruit RNA Polymerase II to the Promoter of Selected Interferon Stimulated Early Response Genes
Sakamoto S, Polta R, Larner AC.
J. Biol. Chem., 279 (39), 40362-40367 (2004)
Identification of a novel conserved motif in the Stat family that is required for tyrosine phosphorylation
Gamero A, Sakamoto S, Montenegro J, Larner AC.
J. Biol. Chem., 279 (13), 12379-12385 (2004)
Cells previously desensitized to type I interferons display different mechanisms on activation of stat-dependent gene expression than naïve cells
Sakamoto S, Qin J, Navarro A, Gamero A, Polta R, Yi T, Zhu W, Baker DP, Feldman G, Larner AC.
J. Biol. Chem., 279 (5), 3245-3253 (2004)
亙俀侽侽俀擭搙亜
Genetic background determines sensitivity to the inhibitory function of NO on T cell proliferation and the amounts of NO production mediated through IFN兞
Ozaki A, Fukushima A, Fukata K, Sakamoto S, Taniguchi T, Hashiguch M, Ueno H.
Microbiology and Immunology, 46(8), 555-563 (2002)
Inhibition of poly (ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a
Song D, Sakamoto S, Taniguchi T.
Biochemistry, 41(3), 929-934 (2002)
亙俀侽侽侾擭搙亜
Identification of a phorbol ester-responsive element in the IFN兞 receptor 1 chain gene
Sakamoto S, Taniguchi T.
J. Biol. Chem., 276(40), 37237-37241 (2001)
Mechanism for maintenance of dominant T helper 1 immune responses in Lewis rats
Sakamoto S, Fukushima A, Ozaki A, Ueno H, Kamakura M, Taniguchi T.
Microbiology and Immunology, 45(5), 373-381 (2001)
Cloning, sequencing, and expression of the meso-diaminopimelate dehydrogenase gene from Bacillus sphaericus
Sakamoto S, Seki M, Nagata S, Misono H.
Journal of Molecular Catalysis: B:Enzymatic, 12, 85-92 (2001)
亙俀侽侽侽擭搙亜
Molecular Characterization and Nuclear Localization of Rat timeless-like Gene Product
Sakamoto S, Miyazaki K, Fukui H, Oishi K, Hayasaka N, Okada M, Kamakura M, Taniguchi T, Nagai K, Ishida N.
Biochem. Biophys. Res. Commun., 279, 131-138 (2000)
亙侾俋俋俋擭搙亜
Identification of Carbonic Anhydrase IV and VI mRNA Expression in Human Pancreas and Salivary Glands
Fujikawa-Adachi K, Nishimori I, Sakamoto S, Morita M, Onishi S, Yonezawa S, Hollingsworth.A M.
Pancreas, 18(4), 329-335 (1999)
Phorbol Ester Induction of IFNg Receptors Leads to Enhanced DR 兛 Gene Expression
Sakamoto S, Nie J, Taniguchi T.
Journal of Immunology, 162, 4381-4384 (1999)
A Binding Protein to the DNase I Hypersensitive Site II in HLA-DR a Gene Was Identified as NF90
Sakamoto S, Morisawa K, Ota K, Nie J, Taniguchi T.
Biochemistry, 38(11), 3355-3361 (1999)
亙侾俋俋俉擭搙亜
Identification of Oct-1 and automodification domain of poly (ADP-ribose) synthetase
Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T.
FEBS Letters, 424, 27-32 (1998)